De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity

De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity

Adipocyte hyperplasia is thought to have beneficial metabolic effects in obesity, but definitive evidence is lacking. Here, Shao et al. promote de novo formation of adipocytes in visceral white adipose tissue (WAT) of adult mice through inducible overexpression of Pparg in Pdgfrβ+ preadipocytes and...

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Autores principales: Mengle Shao, Lavanya Vishvanath, Napoleon C. Busbuso, Chelsea Hepler, Bo Shan, Ankit X. Sharma, Shiuhwei Chen, Xinxin Yu, Yu A. An, Yi Zhu, William L. Holland, Rana K. Gupta
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/6cc640ee069d48bba9a616e022b49eb9
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