Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia

Abstract Restrictive anorexia nervosa is associated with reduced eating and severe body weight loss leading to a cachectic state. Hypothalamus plays a major role in the regulation of food intake and energy homeostasis. In the present study, alterations of hypothalamic proteome and particularly of pr...

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Autores principales:	Séverine Nobis, Alexis Goichon, Najate Achamrah, Charlène Guérin, Saida Azhar, Philippe Chan, Aline Morin, Christine Bôle-Feysot, Jean Claude do Rego, David Vaudry, Pierre Déchelotte, Liliana Belmonte, Moïse Coëffier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6cc907eb7c2d4731b49b52e522bb14ca
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spelling	oai:doaj.org-article:6cc907eb7c2d4731b49b52e522bb14ca2021-12-02T11:41:24ZAlterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia10.1038/s41598-018-25548-92045-2322https://doaj.org/article/6cc907eb7c2d4731b49b52e522bb14ca2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25548-9https://doaj.org/toc/2045-2322Abstract Restrictive anorexia nervosa is associated with reduced eating and severe body weight loss leading to a cachectic state. Hypothalamus plays a major role in the regulation of food intake and energy homeostasis. In the present study, alterations of hypothalamic proteome and particularly of proteins involved in energy and mitochondrial metabolism have been observed in female activity-based anorexia (ABA) mice that exhibited a reduced food intake and a severe weight loss. In the hypothalamus, mitochondrial dynamic was also modified during ABA with an increase of fission without modification of fusion. In addition, increased dynamin-1, and LC3II/LC3I ratio signed an activation of autophagy while protein synthesis was increased. In conclusion, proteomic analysis revealed an adaptive hypothalamic protein response in ABA female mice with both altered mitochondrial response and activated autophagy.Séverine NobisAlexis GoichonNajate AchamrahCharlène GuérinSaida AzharPhilippe ChanAline MorinChristine Bôle-FeysotJean Claude do RegoDavid VaudryPierre DéchelotteLiliana BelmonteMoïse CoëffierNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Séverine Nobis Alexis Goichon Najate Achamrah Charlène Guérin Saida Azhar Philippe Chan Aline Morin Christine Bôle-Feysot Jean Claude do Rego David Vaudry Pierre Déchelotte Liliana Belmonte Moïse Coëffier Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia
description	Abstract Restrictive anorexia nervosa is associated with reduced eating and severe body weight loss leading to a cachectic state. Hypothalamus plays a major role in the regulation of food intake and energy homeostasis. In the present study, alterations of hypothalamic proteome and particularly of proteins involved in energy and mitochondrial metabolism have been observed in female activity-based anorexia (ABA) mice that exhibited a reduced food intake and a severe weight loss. In the hypothalamus, mitochondrial dynamic was also modified during ABA with an increase of fission without modification of fusion. In addition, increased dynamin-1, and LC3II/LC3I ratio signed an activation of autophagy while protein synthesis was increased. In conclusion, proteomic analysis revealed an adaptive hypothalamic protein response in ABA female mice with both altered mitochondrial response and activated autophagy.
format	article
author	Séverine Nobis Alexis Goichon Najate Achamrah Charlène Guérin Saida Azhar Philippe Chan Aline Morin Christine Bôle-Feysot Jean Claude do Rego David Vaudry Pierre Déchelotte Liliana Belmonte Moïse Coëffier
author_facet	Séverine Nobis Alexis Goichon Najate Achamrah Charlène Guérin Saida Azhar Philippe Chan Aline Morin Christine Bôle-Feysot Jean Claude do Rego David Vaudry Pierre Déchelotte Liliana Belmonte Moïse Coëffier
author_sort	Séverine Nobis
title	Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia
title_short	Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia
title_full	Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia
title_fullStr	Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia
title_full_unstemmed	Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia
title_sort	alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6cc907eb7c2d4731b49b52e522bb14ca
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Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia

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