The Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity

As the very low-calorie ketogenic diet (VLCKD) gains increased interest as a therapeutic approach for many diseases, little is known about its therapeutic use in childhood obesity. Indeed, the role of VLCKD during pregnancy and lactation in influencing short chain fatty acid (SCFA)-producing bacteri...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Naser A. Alsharairi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	VLCKD infant gut microbiota obesity adipose tissue SCFAs pregnancy Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/6ccbc6b031ce44c293b60b8adfd83cc8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6ccbc6b031ce44c293b60b8adfd83cc8
record_format	dspace
spelling	oai:doaj.org-article:6ccbc6b031ce44c293b60b8adfd83cc82021-11-25T18:33:18ZThe Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity10.3390/nu131137022072-6643https://doaj.org/article/6ccbc6b031ce44c293b60b8adfd83cc82021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3702https://doaj.org/toc/2072-6643As the very low-calorie ketogenic diet (VLCKD) gains increased interest as a therapeutic approach for many diseases, little is known about its therapeutic use in childhood obesity. Indeed, the role of VLCKD during pregnancy and lactation in influencing short chain fatty acid (SCFA)-producing bacteria and the potential mechanisms involved in the protective effects on obesity are still unclear. Infants are characterized by a diverse gut microbiota composition with higher abundance of SCFA-producing bacteria. Maternal VLCKD during pregnancy and lactation stimulates the growth of diverse species of SCFA-producing bacteria, which may induce epigenetic changes in infant obese gene expression and modulate adipose tissue inflammation in obesity. Therefore, this review aims to determine the mechanistic role of SCFAs in mediating VLCKD-infant gut microbiota relationships and its protective effects on obesity.Naser A. AlsharairiMDPI AGarticleVLCKDinfant gut microbiotaobesityadipose tissueSCFAspregnancyNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3702, p 3702 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	VLCKD infant gut microbiota obesity adipose tissue SCFAs pregnancy Nutrition. Foods and food supply TX341-641
spellingShingle	VLCKD infant gut microbiota obesity adipose tissue SCFAs pregnancy Nutrition. Foods and food supply TX341-641 Naser A. Alsharairi The Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity
description	As the very low-calorie ketogenic diet (VLCKD) gains increased interest as a therapeutic approach for many diseases, little is known about its therapeutic use in childhood obesity. Indeed, the role of VLCKD during pregnancy and lactation in influencing short chain fatty acid (SCFA)-producing bacteria and the potential mechanisms involved in the protective effects on obesity are still unclear. Infants are characterized by a diverse gut microbiota composition with higher abundance of SCFA-producing bacteria. Maternal VLCKD during pregnancy and lactation stimulates the growth of diverse species of SCFA-producing bacteria, which may induce epigenetic changes in infant obese gene expression and modulate adipose tissue inflammation in obesity. Therefore, this review aims to determine the mechanistic role of SCFAs in mediating VLCKD-infant gut microbiota relationships and its protective effects on obesity.
format	article
author	Naser A. Alsharairi
author_facet	Naser A. Alsharairi
author_sort	Naser A. Alsharairi
title	The Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity
title_short	The Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity
title_full	The Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity
title_fullStr	The Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity
title_full_unstemmed	The Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity
title_sort	role of short-chain fatty acids in mediating very low-calorie ketogenic diet-infant gut microbiota relationships and its therapeutic potential in obesity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6ccbc6b031ce44c293b60b8adfd83cc8
work_keys_str_mv	AT naseraalsharairi theroleofshortchainfattyacidsinmediatingverylowcalorieketogenicdietinfantgutmicrobiotarelationshipsanditstherapeuticpotentialinobesity AT naseraalsharairi roleofshortchainfattyacidsinmediatingverylowcalorieketogenicdietinfantgutmicrobiotarelationshipsanditstherapeuticpotentialinobesity
_version_	1718411022727905280

The Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity

Ejemplares similares