Advanced method for fabrication of molecularly imprinted mesoporous organosilica with highly sensitive and selective recognition of glyphosate

Abstract In this study, we synthesized molecularly imprinted mesoporous organosilica (MIMO) in the presence of a new precursor having a zwitterionic functional group and an imprint molecule, namely, glyphosate (MIMO-z). The precursor-glyphosate complex engaged in a typical base-catalyzed sol-gel rea...

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Autores principales:	Youngdo Kim, Jaeho Lee, Ik-Soo Shin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ccd2d4d241847a3afcb2e965b5cf583
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spelling	oai:doaj.org-article:6ccd2d4d241847a3afcb2e965b5cf5832021-12-02T15:08:20ZAdvanced method for fabrication of molecularly imprinted mesoporous organosilica with highly sensitive and selective recognition of glyphosate10.1038/s41598-019-46881-72045-2322https://doaj.org/article/6ccd2d4d241847a3afcb2e965b5cf5832019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46881-7https://doaj.org/toc/2045-2322Abstract In this study, we synthesized molecularly imprinted mesoporous organosilica (MIMO) in the presence of a new precursor having a zwitterionic functional group and an imprint molecule, namely, glyphosate (MIMO-z). The precursor-glyphosate complex engaged in a typical base-catalyzed sol-gel reaction and the introduced zwitterion group remained intact in the framework after the extraction process had been completed. To test the rebinding performance of the target molecule, graphene quantum dots were encapsulated (MIMO-zQ) into pores and the fluorescence intensity change was monitored according to the concentration of glyphosate. When the MIMO-zQ suspension was diluted into the glyphosate solutions, notable fluorescence quenching occurred, right down to sub-nanomolar levels of concentration; 9.2 ± 0.18% quenching at 0.1 nM (0.017 ppb, 17 pg/mL). This result is one of the best reported to date for sensing using MIMO. The synthesized probe also exhibited a distinct signal compared to a series of competing compounds, aminomethylphosphonic acid and glycine; 4.3 ± 0.019% and 3.7 ± 0.041% quenching at 100 nM.Youngdo KimJaeho LeeIk-Soo ShinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Youngdo Kim Jaeho Lee Ik-Soo Shin Advanced method for fabrication of molecularly imprinted mesoporous organosilica with highly sensitive and selective recognition of glyphosate
description	Abstract In this study, we synthesized molecularly imprinted mesoporous organosilica (MIMO) in the presence of a new precursor having a zwitterionic functional group and an imprint molecule, namely, glyphosate (MIMO-z). The precursor-glyphosate complex engaged in a typical base-catalyzed sol-gel reaction and the introduced zwitterion group remained intact in the framework after the extraction process had been completed. To test the rebinding performance of the target molecule, graphene quantum dots were encapsulated (MIMO-zQ) into pores and the fluorescence intensity change was monitored according to the concentration of glyphosate. When the MIMO-zQ suspension was diluted into the glyphosate solutions, notable fluorescence quenching occurred, right down to sub-nanomolar levels of concentration; 9.2 ± 0.18% quenching at 0.1 nM (0.017 ppb, 17 pg/mL). This result is one of the best reported to date for sensing using MIMO. The synthesized probe also exhibited a distinct signal compared to a series of competing compounds, aminomethylphosphonic acid and glycine; 4.3 ± 0.019% and 3.7 ± 0.041% quenching at 100 nM.
format	article
author	Youngdo Kim Jaeho Lee Ik-Soo Shin
author_facet	Youngdo Kim Jaeho Lee Ik-Soo Shin
author_sort	Youngdo Kim
title	Advanced method for fabrication of molecularly imprinted mesoporous organosilica with highly sensitive and selective recognition of glyphosate
title_short	Advanced method for fabrication of molecularly imprinted mesoporous organosilica with highly sensitive and selective recognition of glyphosate
title_full	Advanced method for fabrication of molecularly imprinted mesoporous organosilica with highly sensitive and selective recognition of glyphosate
title_fullStr	Advanced method for fabrication of molecularly imprinted mesoporous organosilica with highly sensitive and selective recognition of glyphosate
title_full_unstemmed	Advanced method for fabrication of molecularly imprinted mesoporous organosilica with highly sensitive and selective recognition of glyphosate
title_sort	advanced method for fabrication of molecularly imprinted mesoporous organosilica with highly sensitive and selective recognition of glyphosate
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6ccd2d4d241847a3afcb2e965b5cf583
work_keys_str_mv	AT youngdokim advancedmethodforfabricationofmolecularlyimprintedmesoporousorganosilicawithhighlysensitiveandselectiverecognitionofglyphosate AT jaeholee advancedmethodforfabricationofmolecularlyimprintedmesoporousorganosilicawithhighlysensitiveandselectiverecognitionofglyphosate AT iksooshin advancedmethodforfabricationofmolecularlyimprintedmesoporousorganosilicawithhighlysensitiveandselectiverecognitionofglyphosate
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Advanced method for fabrication of molecularly imprinted mesoporous organosilica with highly sensitive and selective recognition of glyphosate

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