USP9X regulates centrosome duplication and promotes breast carcinogenesis
USP9X is a deubiquitinating enzyme with many known substrates and functions; it has been linked to cancer but the mechanisms remain unclear. Here Liet al. report that USP9X stabilizes the centrosomal protein CEP131 leading to centrosome amplification and breast cancer development.
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Nature Portfolio
2017
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oai:doaj.org-article:6cceee600b164ac2aaf2e9cf578a0b1a2021-12-02T17:06:07ZUSP9X regulates centrosome duplication and promotes breast carcinogenesis10.1038/ncomms148662041-1723https://doaj.org/article/6cceee600b164ac2aaf2e9cf578a0b1a2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14866https://doaj.org/toc/2041-1723USP9X is a deubiquitinating enzyme with many known substrates and functions; it has been linked to cancer but the mechanisms remain unclear. Here Liet al. report that USP9X stabilizes the centrosomal protein CEP131 leading to centrosome amplification and breast cancer development.Xin LiNan SongLing LiuXinhua LiuXiang DingXin SongShangda YangLin ShanXing ZhouDongxue SuYue WangQi ZhangCheng CaoShuai MaNa YuFuquan YangYan WangZhi YaoYongfeng ShangLei ShiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xin Li Nan Song Ling Liu Xinhua Liu Xiang Ding Xin Song Shangda Yang Lin Shan Xing Zhou Dongxue Su Yue Wang Qi Zhang Cheng Cao Shuai Ma Na Yu Fuquan Yang Yan Wang Zhi Yao Yongfeng Shang Lei Shi USP9X regulates centrosome duplication and promotes breast carcinogenesis |
| description |
USP9X is a deubiquitinating enzyme with many known substrates and functions; it has been linked to cancer but the mechanisms remain unclear. Here Liet al. report that USP9X stabilizes the centrosomal protein CEP131 leading to centrosome amplification and breast cancer development. |
| format |
article |
| author |
Xin Li Nan Song Ling Liu Xinhua Liu Xiang Ding Xin Song Shangda Yang Lin Shan Xing Zhou Dongxue Su Yue Wang Qi Zhang Cheng Cao Shuai Ma Na Yu Fuquan Yang Yan Wang Zhi Yao Yongfeng Shang Lei Shi |
| author_facet |
Xin Li Nan Song Ling Liu Xinhua Liu Xiang Ding Xin Song Shangda Yang Lin Shan Xing Zhou Dongxue Su Yue Wang Qi Zhang Cheng Cao Shuai Ma Na Yu Fuquan Yang Yan Wang Zhi Yao Yongfeng Shang Lei Shi |
| author_sort |
Xin Li |
| title |
USP9X regulates centrosome duplication and promotes breast carcinogenesis |
| title_short |
USP9X regulates centrosome duplication and promotes breast carcinogenesis |
| title_full |
USP9X regulates centrosome duplication and promotes breast carcinogenesis |
| title_fullStr |
USP9X regulates centrosome duplication and promotes breast carcinogenesis |
| title_full_unstemmed |
USP9X regulates centrosome duplication and promotes breast carcinogenesis |
| title_sort |
usp9x regulates centrosome duplication and promotes breast carcinogenesis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/6cceee600b164ac2aaf2e9cf578a0b1a |
| work_keys_str_mv |
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