Sauna dehydration as a new physiological challenge model for intestinal barrier function

Abstract The intestinal barrier plays a crucial role in maintaining gut health, and an increased permeability has been linked to several intestinal and extra-intestinal disorders. There is an increasing demand for interventions aimed at strengthening this barrier and for in vivo challenge models to...

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Autores principales:	Maria Fernanda Roca Rubio, Ulrika Eriksson, Robert J. Brummer, Julia König
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6cd0160ba910430e9a6b380a86611eaa
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spelling	oai:doaj.org-article:6cd0160ba910430e9a6b380a86611eaa2021-12-02T18:46:57ZSauna dehydration as a new physiological challenge model for intestinal barrier function10.1038/s41598-021-94814-02045-2322https://doaj.org/article/6cd0160ba910430e9a6b380a86611eaa2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94814-0https://doaj.org/toc/2045-2322Abstract The intestinal barrier plays a crucial role in maintaining gut health, and an increased permeability has been linked to several intestinal and extra-intestinal disorders. There is an increasing demand for interventions aimed at strengthening this barrier and for in vivo challenge models to assess their efficiency. This study investigated the effect of sauna-induced dehydration on intestinal barrier function (clinicaltrials.gov: NCT03620825). Twenty healthy subjects underwent three conditions in random order: (1) Sauna dehydration (loss of 3% body weight), (2) non-steroidal anti-inflammatory drug (NSAID) intake, (3) negative control. Intestinal permeability was assessed by a multi-sugar urinary recovery test, while intestinal damage, bacterial translocation and cytokines were assessed by plasma markers. The sauna dehydration protocol resulted in an increase in gastroduodenal and small intestinal permeability. Presumably, this increase occurred without substantial damage to the enterocytes as plasma intestinal fatty acid-binding protein (I-FABP) and liver fatty acid-binding protein (L-FABP) were not affected. In addition, we observed significant increases in levels of lipopolysaccharide-binding protein (LBP), IL-6 and IL-8, while sCD14, IL-10, IFN-ɣ and TNF-α were not affected. These results suggest that sauna dehydration increased intestinal permeability and could be applied as a new physiological in vivo challenge model for intestinal barrier function.Maria Fernanda Roca RubioUlrika ErikssonRobert J. BrummerJulia KönigNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Fernanda Roca Rubio Ulrika Eriksson Robert J. Brummer Julia König Sauna dehydration as a new physiological challenge model for intestinal barrier function
description	Abstract The intestinal barrier plays a crucial role in maintaining gut health, and an increased permeability has been linked to several intestinal and extra-intestinal disorders. There is an increasing demand for interventions aimed at strengthening this barrier and for in vivo challenge models to assess their efficiency. This study investigated the effect of sauna-induced dehydration on intestinal barrier function (clinicaltrials.gov: NCT03620825). Twenty healthy subjects underwent three conditions in random order: (1) Sauna dehydration (loss of 3% body weight), (2) non-steroidal anti-inflammatory drug (NSAID) intake, (3) negative control. Intestinal permeability was assessed by a multi-sugar urinary recovery test, while intestinal damage, bacterial translocation and cytokines were assessed by plasma markers. The sauna dehydration protocol resulted in an increase in gastroduodenal and small intestinal permeability. Presumably, this increase occurred without substantial damage to the enterocytes as plasma intestinal fatty acid-binding protein (I-FABP) and liver fatty acid-binding protein (L-FABP) were not affected. In addition, we observed significant increases in levels of lipopolysaccharide-binding protein (LBP), IL-6 and IL-8, while sCD14, IL-10, IFN-ɣ and TNF-α were not affected. These results suggest that sauna dehydration increased intestinal permeability and could be applied as a new physiological in vivo challenge model for intestinal barrier function.
format	article
author	Maria Fernanda Roca Rubio Ulrika Eriksson Robert J. Brummer Julia König
author_facet	Maria Fernanda Roca Rubio Ulrika Eriksson Robert J. Brummer Julia König
author_sort	Maria Fernanda Roca Rubio
title	Sauna dehydration as a new physiological challenge model for intestinal barrier function
title_short	Sauna dehydration as a new physiological challenge model for intestinal barrier function
title_full	Sauna dehydration as a new physiological challenge model for intestinal barrier function
title_fullStr	Sauna dehydration as a new physiological challenge model for intestinal barrier function
title_full_unstemmed	Sauna dehydration as a new physiological challenge model for intestinal barrier function
title_sort	sauna dehydration as a new physiological challenge model for intestinal barrier function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6cd0160ba910430e9a6b380a86611eaa
work_keys_str_mv	AT mariafernandarocarubio saunadehydrationasanewphysiologicalchallengemodelforintestinalbarrierfunction AT ulrikaeriksson saunadehydrationasanewphysiologicalchallengemodelforintestinalbarrierfunction AT robertjbrummer saunadehydrationasanewphysiologicalchallengemodelforintestinalbarrierfunction AT juliakonig saunadehydrationasanewphysiologicalchallengemodelforintestinalbarrierfunction
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Sauna dehydration as a new physiological challenge model for intestinal barrier function

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