Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling

ARMMs are extracellular vesicles that bud directly at the plasma membrane; their function is poorly understood. Here the authors purify and carryout a proteomics analysis of the protein components of ARMMs, and show that NOTCH receptors are recruited into ARMMs and can be transferred to recipient ce...

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Autores principales:	Qiyu Wang, Quan Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6cd303323cdc4b21a1380570c3dfea21
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spelling	oai:doaj.org-article:6cd303323cdc4b21a1380570c3dfea212021-12-02T15:36:58ZPlasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling10.1038/s41467-017-00767-22041-1723https://doaj.org/article/6cd303323cdc4b21a1380570c3dfea212017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00767-2https://doaj.org/toc/2041-1723ARMMs are extracellular vesicles that bud directly at the plasma membrane; their function is poorly understood. Here the authors purify and carryout a proteomics analysis of the protein components of ARMMs, and show that NOTCH receptors are recruited into ARMMs and can be transferred to recipient cells to mediate NOTCH signaling.Qiyu WangQuan LuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiyu Wang Quan Lu Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling
description	ARMMs are extracellular vesicles that bud directly at the plasma membrane; their function is poorly understood. Here the authors purify and carryout a proteomics analysis of the protein components of ARMMs, and show that NOTCH receptors are recruited into ARMMs and can be transferred to recipient cells to mediate NOTCH signaling.
format	article
author	Qiyu Wang Quan Lu
author_facet	Qiyu Wang Quan Lu
author_sort	Qiyu Wang
title	Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling
title_short	Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling
title_full	Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling
title_fullStr	Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling
title_full_unstemmed	Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling
title_sort	plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular notch signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6cd303323cdc4b21a1380570c3dfea21
work_keys_str_mv	AT qiyuwang plasmamembranederivedextracellularmicrovesiclesmediatenoncanonicalintercellularnotchsignaling AT quanlu plasmamembranederivedextracellularmicrovesiclesmediatenoncanonicalintercellularnotchsignaling
_version_	1718386294269149184

Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling

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