Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer

The use of of CDK4/6 inhibitors to treat patients with TNBC is limited by loss of Rb. Here, the authors show that a combination of CDK4/6 inhibitor and EGFR inhibitor is effective against DEDD-overexpressing TNBC, independent of Rb status.

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Autores principales:	Yingjia Ni, Keon R. Schmidt, Barnes A. Werner, Jenna K. Koenig, Ian H. Guldner, Patricia M. Schnepp, Xuejuan Tan, Lan Jiang, Misha Host, Longhua Sun, Erin N. Howe, Junmin Wu, Laurie E. Littlepage, Harikrishna Nakshatri, Siyuan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6cd4e5da2a3943ceb86081cf1bcee7ae
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spelling	oai:doaj.org-article:6cd4e5da2a3943ceb86081cf1bcee7ae2021-12-02T14:39:42ZDeath effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer10.1038/s41467-019-10743-72041-1723https://doaj.org/article/6cd4e5da2a3943ceb86081cf1bcee7ae2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10743-7https://doaj.org/toc/2041-1723The use of of CDK4/6 inhibitors to treat patients with TNBC is limited by loss of Rb. Here, the authors show that a combination of CDK4/6 inhibitor and EGFR inhibitor is effective against DEDD-overexpressing TNBC, independent of Rb status.Yingjia NiKeon R. SchmidtBarnes A. WernerJenna K. KoenigIan H. GuldnerPatricia M. SchneppXuejuan TanLan JiangMisha HostLonghua SunErin N. HoweJunmin WuLaurie E. LittlepageHarikrishna NakshatriSiyuan ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingjia Ni Keon R. Schmidt Barnes A. Werner Jenna K. Koenig Ian H. Guldner Patricia M. Schnepp Xuejuan Tan Lan Jiang Misha Host Longhua Sun Erin N. Howe Junmin Wu Laurie E. Littlepage Harikrishna Nakshatri Siyuan Zhang Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer
description	The use of of CDK4/6 inhibitors to treat patients with TNBC is limited by loss of Rb. Here, the authors show that a combination of CDK4/6 inhibitor and EGFR inhibitor is effective against DEDD-overexpressing TNBC, independent of Rb status.
format	article
author	Yingjia Ni Keon R. Schmidt Barnes A. Werner Jenna K. Koenig Ian H. Guldner Patricia M. Schnepp Xuejuan Tan Lan Jiang Misha Host Longhua Sun Erin N. Howe Junmin Wu Laurie E. Littlepage Harikrishna Nakshatri Siyuan Zhang
author_facet	Yingjia Ni Keon R. Schmidt Barnes A. Werner Jenna K. Koenig Ian H. Guldner Patricia M. Schnepp Xuejuan Tan Lan Jiang Misha Host Longhua Sun Erin N. Howe Junmin Wu Laurie E. Littlepage Harikrishna Nakshatri Siyuan Zhang
author_sort	Yingjia Ni
title	Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer
title_short	Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer
title_full	Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer
title_fullStr	Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer
title_full_unstemmed	Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer
title_sort	death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6cd4e5da2a3943ceb86081cf1bcee7ae
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Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer

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