Predicting Gleason score using the initial serum total prostate-specific antigen in Black men with symptomatic prostate adenocarcinoma in Nigeria

Ikenna I Nnabugwu, Emeka I Udeh, Fredrick O Ugwumba, Francis O Ozoemena Urology Unit, Department of Surgery, College of Medicine, Enugu Campus, University of Nigeria, Enugu, Nigeria Background: Men of Black African descent are known to have the highest incidence of prostate cancer. The disease is...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nnabugwu II, Udeh EI, Ugwumba FO, Ozoemena FO
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Keywords: PSA Patient age Prostate volume Prostate adenocarcinoma Gleason score. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/6cd86bb5e187418097fc97a7bbbb615a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6cd86bb5e187418097fc97a7bbbb615a
record_format	dspace
spelling	oai:doaj.org-article:6cd86bb5e187418097fc97a7bbbb615a2021-12-02T04:10:07ZPredicting Gleason score using the initial serum total prostate-specific antigen in Black men with symptomatic prostate adenocarcinoma in Nigeria1178-1998https://doaj.org/article/6cd86bb5e187418097fc97a7bbbb615a2016-07-01T00:00:00Zhttps://www.dovepress.com/predicting-gleason-score-using-the-initial-serum-total-prostate-specif-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ikenna I Nnabugwu, Emeka I Udeh, Fredrick O Ugwumba, Francis O Ozoemena Urology Unit, Department of Surgery, College of Medicine, Enugu Campus, University of Nigeria, Enugu, Nigeria Background: Men of Black African descent are known to have the highest incidence of prostate cancer. The disease is also more aggressive in this group possibly due to biologically more aggressive tumor or late presentation. Currently, serum prostate-specific antigen (PSA) assay plays a significant role in making the diagnosis of prostate cancer. However, the obtained value of serum PSA may not directly relate with the Gleason score (GS), a measure of tumor aggression in prostate cancer. This study explores the relationship between serum total PSA at presentation (iPSA) and GS.Patients and methods: The iPSA of patients with histologically confirmed prostate cancer was compared with the obtained GS of the prostate biopsy specimens. The age of the patients at presentation and the prostate volumes were also analyzed with respect to the iPSA and GS. The data were analyzed retrospectively using IBM SPSS Version 20. Pearson correlation was used for numeric variables, whereas Fisher’s exact test was used for categorical variables. Significance was set at P≤0.05.Results: There were 205 patients from January 2010 to November 2013 who satisfied the inclusion criteria. iPSA as well as age at presentation and prostate volume were not found to significantly correlate with the primary Gleason grade, the secondary Gleason grade, or the GS. However, the presence of distant metastasis was identified to significantly correlate positively with GS.Conclusion: GS may not be confidently predicted by the iPSA. Higher iPSA does not correlate with higher GS and vice versa. Keywords: PSA, patient age, prostate volume, prostate adenocarcinoma, Gleason scoreNnabugwu IIUdeh EIUgwumba FOOzoemena FODove Medical PressarticleKeywords: PSAPatient ageProstate volumeProstate adenocarcinomaGleason score.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 961-966 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Keywords: PSA Patient age Prostate volume Prostate adenocarcinoma Gleason score. Geriatrics RC952-954.6
spellingShingle	Keywords: PSA Patient age Prostate volume Prostate adenocarcinoma Gleason score. Geriatrics RC952-954.6 Nnabugwu II Udeh EI Ugwumba FO Ozoemena FO Predicting Gleason score using the initial serum total prostate-specific antigen in Black men with symptomatic prostate adenocarcinoma in Nigeria
description	Ikenna I Nnabugwu, Emeka I Udeh, Fredrick O Ugwumba, Francis O Ozoemena Urology Unit, Department of Surgery, College of Medicine, Enugu Campus, University of Nigeria, Enugu, Nigeria Background: Men of Black African descent are known to have the highest incidence of prostate cancer. The disease is also more aggressive in this group possibly due to biologically more aggressive tumor or late presentation. Currently, serum prostate-specific antigen (PSA) assay plays a significant role in making the diagnosis of prostate cancer. However, the obtained value of serum PSA may not directly relate with the Gleason score (GS), a measure of tumor aggression in prostate cancer. This study explores the relationship between serum total PSA at presentation (iPSA) and GS.Patients and methods: The iPSA of patients with histologically confirmed prostate cancer was compared with the obtained GS of the prostate biopsy specimens. The age of the patients at presentation and the prostate volumes were also analyzed with respect to the iPSA and GS. The data were analyzed retrospectively using IBM SPSS Version 20. Pearson correlation was used for numeric variables, whereas Fisher’s exact test was used for categorical variables. Significance was set at P≤0.05.Results: There were 205 patients from January 2010 to November 2013 who satisfied the inclusion criteria. iPSA as well as age at presentation and prostate volume were not found to significantly correlate with the primary Gleason grade, the secondary Gleason grade, or the GS. However, the presence of distant metastasis was identified to significantly correlate positively with GS.Conclusion: GS may not be confidently predicted by the iPSA. Higher iPSA does not correlate with higher GS and vice versa. Keywords: PSA, patient age, prostate volume, prostate adenocarcinoma, Gleason score
format	article
author	Nnabugwu II Udeh EI Ugwumba FO Ozoemena FO
author_facet	Nnabugwu II Udeh EI Ugwumba FO Ozoemena FO
author_sort	Nnabugwu II
title	Predicting Gleason score using the initial serum total prostate-specific antigen in Black men with symptomatic prostate adenocarcinoma in Nigeria
title_short	Predicting Gleason score using the initial serum total prostate-specific antigen in Black men with symptomatic prostate adenocarcinoma in Nigeria
title_full	Predicting Gleason score using the initial serum total prostate-specific antigen in Black men with symptomatic prostate adenocarcinoma in Nigeria
title_fullStr	Predicting Gleason score using the initial serum total prostate-specific antigen in Black men with symptomatic prostate adenocarcinoma in Nigeria
title_full_unstemmed	Predicting Gleason score using the initial serum total prostate-specific antigen in Black men with symptomatic prostate adenocarcinoma in Nigeria
title_sort	predicting gleason score using the initial serum total prostate-specific antigen in black men with symptomatic prostate adenocarcinoma in nigeria
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/6cd86bb5e187418097fc97a7bbbb615a
work_keys_str_mv	AT nnabugwuii predictinggleasonscoreusingtheinitialserumtotalprostatespecificantigeninblackmenwithsymptomaticprostateadenocarcinomainnigeria AT udehei predictinggleasonscoreusingtheinitialserumtotalprostatespecificantigeninblackmenwithsymptomaticprostateadenocarcinomainnigeria AT ugwumbafo predictinggleasonscoreusingtheinitialserumtotalprostatespecificantigeninblackmenwithsymptomaticprostateadenocarcinomainnigeria AT ozoemenafo predictinggleasonscoreusingtheinitialserumtotalprostatespecificantigeninblackmenwithsymptomaticprostateadenocarcinomainnigeria
_version_	1718401376646594560

Predicting Gleason score using the initial serum total prostate-specific antigen in Black men with symptomatic prostate adenocarcinoma in Nigeria

Ejemplares similares