An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?

A better understanding of co-evolution between pathogens and hosts holds promise for better prevention and control strategies. This review will explore the interactions between Burkholderia pseudomallei, an environmental and opportunistic pathogen, and the human host immune system. B. pseudomallei c...

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Autores principales:	Chalita Chomkatekaew, Phumrapee Boonklang, Apiwat Sangphukieo, Claire Chewapreecha
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	melioidosis evolution burkholderia host immune system genetic variants Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6cd8e2a933cd40969b98238221624d7a
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spelling	oai:doaj.org-article:6cd8e2a933cd40969b98238221624d7a2021-11-30T14:46:02ZAn Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?1664-302X10.3389/fmicb.2020.612568https://doaj.org/article/6cd8e2a933cd40969b98238221624d7a2021-01-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2020.612568/fullhttps://doaj.org/toc/1664-302XA better understanding of co-evolution between pathogens and hosts holds promise for better prevention and control strategies. This review will explore the interactions between Burkholderia pseudomallei, an environmental and opportunistic pathogen, and the human host immune system. B. pseudomallei causes “Melioidosis,” a rapidly fatal tropical infectious disease predicted to affect 165,000 cases annually worldwide, of which 89,000 are fatal. Genetic heterogeneities were reported in both B. pseudomallei and human host population, some of which may, at least in part, contribute to inter-individual differences in disease susceptibility. Here, we review (i) a multi-host—pathogen characteristic of the interaction; (ii) selection pressures acting on B. pseudomallei and human genomes with the former being driven by bacterial adaptation across ranges of ecological niches while the latter are driven by human encounter of broad ranges of pathogens; (iii) the mechanisms that generate genetic diversity in bacterial and host population particularly in sequences encoding proteins functioning in host—pathogen interaction; (iv) reported genetic and structural variations of proteins or molecules observed in B. pseudomallei—human host interactions and their implications in infection outcomes. Together, these predict bacterial and host evolutionary trajectory which continues to generate genetic diversity in bacterium and operates host immune selection at the molecular level.Chalita ChomkatekaewPhumrapee BoonklangApiwat SangphukieoApiwat SangphukieoClaire ChewapreechaClaire ChewapreechaClaire ChewapreechaFrontiers Media S.A.articlemelioidosisevolutionburkholderiahost immune systemgenetic variantsMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	melioidosis evolution burkholderia host immune system genetic variants Microbiology QR1-502
spellingShingle	melioidosis evolution burkholderia host immune system genetic variants Microbiology QR1-502 Chalita Chomkatekaew Phumrapee Boonklang Apiwat Sangphukieo Apiwat Sangphukieo Claire Chewapreecha Claire Chewapreecha Claire Chewapreecha An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?
description	A better understanding of co-evolution between pathogens and hosts holds promise for better prevention and control strategies. This review will explore the interactions between Burkholderia pseudomallei, an environmental and opportunistic pathogen, and the human host immune system. B. pseudomallei causes “Melioidosis,” a rapidly fatal tropical infectious disease predicted to affect 165,000 cases annually worldwide, of which 89,000 are fatal. Genetic heterogeneities were reported in both B. pseudomallei and human host population, some of which may, at least in part, contribute to inter-individual differences in disease susceptibility. Here, we review (i) a multi-host—pathogen characteristic of the interaction; (ii) selection pressures acting on B. pseudomallei and human genomes with the former being driven by bacterial adaptation across ranges of ecological niches while the latter are driven by human encounter of broad ranges of pathogens; (iii) the mechanisms that generate genetic diversity in bacterial and host population particularly in sequences encoding proteins functioning in host—pathogen interaction; (iv) reported genetic and structural variations of proteins or molecules observed in B. pseudomallei—human host interactions and their implications in infection outcomes. Together, these predict bacterial and host evolutionary trajectory which continues to generate genetic diversity in bacterium and operates host immune selection at the molecular level.
format	article
author	Chalita Chomkatekaew Phumrapee Boonklang Apiwat Sangphukieo Apiwat Sangphukieo Claire Chewapreecha Claire Chewapreecha Claire Chewapreecha
author_facet	Chalita Chomkatekaew Phumrapee Boonklang Apiwat Sangphukieo Apiwat Sangphukieo Claire Chewapreecha Claire Chewapreecha Claire Chewapreecha
author_sort	Chalita Chomkatekaew
title	An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?
title_short	An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?
title_full	An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?
title_fullStr	An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?
title_full_unstemmed	An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?
title_sort	evolutionary arms race between burkholderia pseudomallei and host immune system: what do we know?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6cd8e2a933cd40969b98238221624d7a
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An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?

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