Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy
An amino acid exchange (P209L) in the human co-chaperone BAG3 gives rise to severe childhood restrictive cardiomyopathy. Here the authors describe humanized transgenic mouse models which phenocopy the disease and provide insight into the pathogenic mechanisms.
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Nature Portfolio
2021
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oai:doaj.org-article:6cdac892607d45f6a6225c942b322a422021-12-02T15:02:50ZOverexpression of human BAG3P209L in mice causes restrictive cardiomyopathy10.1038/s41467-021-23858-72041-1723https://doaj.org/article/6cdac892607d45f6a6225c942b322a422021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23858-7https://doaj.org/toc/2041-1723An amino acid exchange (P209L) in the human co-chaperone BAG3 gives rise to severe childhood restrictive cardiomyopathy. Here the authors describe humanized transgenic mouse models which phenocopy the disease and provide insight into the pathogenic mechanisms.Kenichi KimuraAstrid OomsKathrin Graf-RiesenMaithreyan KuppusamyAndreas UngerJulia SchuldJan DaerrAchim LotherCaroline GeisenLutz HeinSatoru TakahashiGuang LiWilhelm RöllWilhelm BlochPeter F. M. van der VenWolfgang A. LinkeSean M. WuPitter F. HuesgenJörg HöhfeldDieter O. FürstBernd K. FleischmannMichael HesseNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Kenichi Kimura Astrid Ooms Kathrin Graf-Riesen Maithreyan Kuppusamy Andreas Unger Julia Schuld Jan Daerr Achim Lother Caroline Geisen Lutz Hein Satoru Takahashi Guang Li Wilhelm Röll Wilhelm Bloch Peter F. M. van der Ven Wolfgang A. Linke Sean M. Wu Pitter F. Huesgen Jörg Höhfeld Dieter O. Fürst Bernd K. Fleischmann Michael Hesse Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy |
| description |
An amino acid exchange (P209L) in the human co-chaperone BAG3 gives rise to severe childhood restrictive cardiomyopathy. Here the authors describe humanized transgenic mouse models which phenocopy the disease and provide insight into the pathogenic mechanisms. |
| format |
article |
| author |
Kenichi Kimura Astrid Ooms Kathrin Graf-Riesen Maithreyan Kuppusamy Andreas Unger Julia Schuld Jan Daerr Achim Lother Caroline Geisen Lutz Hein Satoru Takahashi Guang Li Wilhelm Röll Wilhelm Bloch Peter F. M. van der Ven Wolfgang A. Linke Sean M. Wu Pitter F. Huesgen Jörg Höhfeld Dieter O. Fürst Bernd K. Fleischmann Michael Hesse |
| author_facet |
Kenichi Kimura Astrid Ooms Kathrin Graf-Riesen Maithreyan Kuppusamy Andreas Unger Julia Schuld Jan Daerr Achim Lother Caroline Geisen Lutz Hein Satoru Takahashi Guang Li Wilhelm Röll Wilhelm Bloch Peter F. M. van der Ven Wolfgang A. Linke Sean M. Wu Pitter F. Huesgen Jörg Höhfeld Dieter O. Fürst Bernd K. Fleischmann Michael Hesse |
| author_sort |
Kenichi Kimura |
| title |
Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy |
| title_short |
Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy |
| title_full |
Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy |
| title_fullStr |
Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy |
| title_full_unstemmed |
Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy |
| title_sort |
overexpression of human bag3p209l in mice causes restrictive cardiomyopathy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/6cdac892607d45f6a6225c942b322a42 |
| work_keys_str_mv |
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| _version_ |
1718389084111503360 |