Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma

Hepatitis E virus infections are the leading cause of viral hepatitis in humans, contributing to an estimated 3.3 million symptomatic cases and almost 44,000 deaths annually. Recently, HEV infections have been found to result in chronic liver infection and cirrhosis in severely immunocompromised pat...

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Autores principales:	Mara Klöhn, Jil Alexandra Schrader, Yannick Brüggemann, Daniel Todt, Eike Steinmann
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatitis E virus hepatocellular carcinoma chronic infection carcinogenesis oncovirus Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6cdd1289c40c4d24905a962dac34477f
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spelling	oai:doaj.org-article:6cdd1289c40c4d24905a962dac34477f2021-11-25T17:04:55ZBeyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma10.3390/cancers132258672072-6694https://doaj.org/article/6cdd1289c40c4d24905a962dac34477f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5867https://doaj.org/toc/2072-6694Hepatitis E virus infections are the leading cause of viral hepatitis in humans, contributing to an estimated 3.3 million symptomatic cases and almost 44,000 deaths annually. Recently, HEV infections have been found to result in chronic liver infection and cirrhosis in severely immunocompromised patients, suggesting the possibility of HEV-induced hepatocarcinogenesis. While HEV-associated formation of HCC has rarely been reported, the expansion of HEV’s clinical spectrum and the increasing evidence of chronic HEV infections raise questions about the connection between HEV and HCC. The present review summarizes current clinical evidence of the relationship between HEV and HCC and discusses mechanisms of virus-induced HCC development with regard to HEV pathogenesis. We further elucidate why the development of HEV-induced hepatocellular carcinoma has so rarely been observed and provide an outlook on possible experimental set-ups to study the relationship between HEV and HCC formation.Mara KlöhnJil Alexandra SchraderYannick BrüggemannDaniel TodtEike SteinmannMDPI AGarticlehepatitis E virushepatocellular carcinomachronic infectioncarcinogenesisoncovirusNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5867, p 5867 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatitis E virus hepatocellular carcinoma chronic infection carcinogenesis oncovirus Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatitis E virus hepatocellular carcinoma chronic infection carcinogenesis oncovirus Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mara Klöhn Jil Alexandra Schrader Yannick Brüggemann Daniel Todt Eike Steinmann Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma
description	Hepatitis E virus infections are the leading cause of viral hepatitis in humans, contributing to an estimated 3.3 million symptomatic cases and almost 44,000 deaths annually. Recently, HEV infections have been found to result in chronic liver infection and cirrhosis in severely immunocompromised patients, suggesting the possibility of HEV-induced hepatocarcinogenesis. While HEV-associated formation of HCC has rarely been reported, the expansion of HEV’s clinical spectrum and the increasing evidence of chronic HEV infections raise questions about the connection between HEV and HCC. The present review summarizes current clinical evidence of the relationship between HEV and HCC and discusses mechanisms of virus-induced HCC development with regard to HEV pathogenesis. We further elucidate why the development of HEV-induced hepatocellular carcinoma has so rarely been observed and provide an outlook on possible experimental set-ups to study the relationship between HEV and HCC formation.
format	article
author	Mara Klöhn Jil Alexandra Schrader Yannick Brüggemann Daniel Todt Eike Steinmann
author_facet	Mara Klöhn Jil Alexandra Schrader Yannick Brüggemann Daniel Todt Eike Steinmann
author_sort	Mara Klöhn
title	Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma
title_short	Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma
title_full	Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma
title_fullStr	Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma
title_full_unstemmed	Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma
title_sort	beyond the usual suspects: hepatitis e virus and its implications in hepatocellular carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6cdd1289c40c4d24905a962dac34477f
work_keys_str_mv	AT maraklohn beyondtheusualsuspectshepatitisevirusanditsimplicationsinhepatocellularcarcinoma AT jilalexandraschrader beyondtheusualsuspectshepatitisevirusanditsimplicationsinhepatocellularcarcinoma AT yannickbruggemann beyondtheusualsuspectshepatitisevirusanditsimplicationsinhepatocellularcarcinoma AT danieltodt beyondtheusualsuspectshepatitisevirusanditsimplicationsinhepatocellularcarcinoma AT eikesteinmann beyondtheusualsuspectshepatitisevirusanditsimplicationsinhepatocellularcarcinoma
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Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma

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