Aging, human immunodeficiency virus, and bone health

Kim C ManskyDivision of Orthodontics, Department of Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USAAbstract: Highly active antiretroviral therapy (HAART) has had a profound impact on improving the long-term prognosis for individuals infected wi...

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Autor principal: Kim C Mansky
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Lenguaje:EN
Publicado: Dove Medical Press 2010
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Acceso en línea:https://doaj.org/article/6ce0a2e3e98b4b69861e7bf71d9f858a
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spelling oai:doaj.org-article:6ce0a2e3e98b4b69861e7bf71d9f858a2021-12-02T07:35:33ZAging, human immunodeficiency virus, and bone health1178-1998https://doaj.org/article/6ce0a2e3e98b4b69861e7bf71d9f858a2010-09-01T00:00:00Zhttps://www.dovepress.com/aging-human-immunodeficiency-virus-and-bone-health-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Kim C ManskyDivision of Orthodontics, Department of Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USAAbstract: Highly active antiretroviral therapy (HAART) has had a profound impact on improving the long-term prognosis for individuals infected with human immunodeficiency virus (HIV). HAART has been available for close to two decades, and now a significant number of patients with access to HAART are over the age of 50 years. Many clinical studies have indicated that HIV infection, as well as components of HAART, can increase the risk in these individuals to a variety of noninfectious complications, including a risk to bone health. There is a significant need for detailed mechanistic analysis of the aging, HIV-infected population regarding the risk of HIV infection and therapy in order to maintain bone health. Insights from basic mechanistic studies will help to shed light on the role of HIV infection and the components of HAART that impact bone health, and will help in identifying preventative countermeasures, particularly for individuals 50 years of age and older.Keywords: osteopenia, osteomalacia, osteoporosis, bisphosphonates, tenofovir, osteoimmunologyKim C ManskyDove Medical PressarticleosteopeniaosteomalaciaosteoporosisbisphosphatestenofovirosteoimmunologyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 5, Pp 285-292 (2010)
institution DOAJ
collection DOAJ
language EN
topic osteopenia
osteomalacia
osteoporosis
bisphosphates
tenofovir
osteoimmunology
Geriatrics
RC952-954.6
spellingShingle osteopenia
osteomalacia
osteoporosis
bisphosphates
tenofovir
osteoimmunology
Geriatrics
RC952-954.6
Kim C Mansky
Aging, human immunodeficiency virus, and bone health
description Kim C ManskyDivision of Orthodontics, Department of Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USAAbstract: Highly active antiretroviral therapy (HAART) has had a profound impact on improving the long-term prognosis for individuals infected with human immunodeficiency virus (HIV). HAART has been available for close to two decades, and now a significant number of patients with access to HAART are over the age of 50 years. Many clinical studies have indicated that HIV infection, as well as components of HAART, can increase the risk in these individuals to a variety of noninfectious complications, including a risk to bone health. There is a significant need for detailed mechanistic analysis of the aging, HIV-infected population regarding the risk of HIV infection and therapy in order to maintain bone health. Insights from basic mechanistic studies will help to shed light on the role of HIV infection and the components of HAART that impact bone health, and will help in identifying preventative countermeasures, particularly for individuals 50 years of age and older.Keywords: osteopenia, osteomalacia, osteoporosis, bisphosphonates, tenofovir, osteoimmunology
format article
author Kim C Mansky
author_facet Kim C Mansky
author_sort Kim C Mansky
title Aging, human immunodeficiency virus, and bone health
title_short Aging, human immunodeficiency virus, and bone health
title_full Aging, human immunodeficiency virus, and bone health
title_fullStr Aging, human immunodeficiency virus, and bone health
title_full_unstemmed Aging, human immunodeficiency virus, and bone health
title_sort aging, human immunodeficiency virus, and bone health
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/6ce0a2e3e98b4b69861e7bf71d9f858a
work_keys_str_mv AT kimcmansky aginghumanimmunodeficiencyvirusandbonehealth
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