Pharmacometabolomics identifies candidate predictor metabolites of an L‐carnitine treatment mortality benefit in septic shock

Abstract Sepsis‐induced metabolic dysfunction contributes to organ failure and death. L‐carnitine has shown promise for septic shock, but a recent phase II study of patients with vasopressor‐dependent septic shock demonstrated a non‐significant reduction in mortality. We undertook a pharmacometabolo...

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Main Authors: Michael A. Puskarich, Theodore S. Jennaro, Christopher E. Gillies, Charles R. Evans, Alla Karnovsky, Cora E. McHugh, Thomas L. Flott, Alan E. Jones, Kathleen A. Stringer, for the RACE Investigators
Format: article
Language:EN
Published: Wiley 2021
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Online Access:https://doaj.org/article/6ce1ffd631774c4e9df4a19cf077f90d
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