Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy

Jian Fang,1,* Shangwu Zhang,2,* Xiaofeng Xue,3 Xinguo Zhu,3 Shiduo Song,3 Bin Wang,3 Linhua Jiang,3 Mingde Qin,4 Hansi Liang,4 Ling Gao3 1Department of General Surgery, Zhangjiagang Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, People’s Republic of China; 2Departmen...

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Autores principales:	Fang J, Zhang S, Xue X, Zhu X, Song S, Wang B, Jiang L, Qin M, Liang H, Gao L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	gastric carcinoma chemotherapy quercetin doxorubicin co-delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6ce561a726ae4955bd358c35d4d6941c
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spelling	oai:doaj.org-article:6ce561a726ae4955bd358c35d4d6941c2021-12-02T02:55:17ZQuercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy1178-2013https://doaj.org/article/6ce561a726ae4955bd358c35d4d6941c2018-09-01T00:00:00Zhttps://www.dovepress.com/quercetin-and-doxorubicin-co-delivery-using-mesoporous-silica-nanopart-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jian Fang,1,* Shangwu Zhang,2,* Xiaofeng Xue,3 Xinguo Zhu,3 Shiduo Song,3 Bin Wang,3 Linhua Jiang,3 Mingde Qin,4 Hansi Liang,4 Ling Gao3 1Department of General Surgery, Zhangjiagang Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, People’s Republic of China; 2Department of Emergency Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, People’s Republic of China; 3Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, People’s Republic of China; 4Department of General Surgery, The Stem Cell and Biomedical Material Key Laboratory of Jiangsu Province (The State Key Laboratory Incubation Base), Soochow University, Suzhou, Jiangsu Province, People’s Republic of China *These authors contributed equally to this work Background: Effective gastric carcinoma (GC) chemotherapy is subject to many in vitro and in vivo barriers, such as tumor microenvironment and multidrug resistance. Materials and methods: Herein, we developed a hyaluronic acid (HA)-modified silica nanoparticle (HA-SiLN/QD) co-delivering quercetin and doxorubicin (DOX) to enhance the efficacy of GC therapy (HA-SiLN/QD). The HA modification was done to recognize overexpressed CD44 receptors on GC cells and mediate selective tumor targeting. In parallel, quercetin delivery decreased the expression of Wnt16 and P-glycoprotein, thus remodeling the tumor microenvironment and reversed multidrug resistance to facilitate DOX activity. Results: Experimental results demonstrated that HA-SiLN/QD was nanoscaled particles with preferable stability and sustained release property. In vitro cell experiments on SGC7901/ADR cells showed selective uptake and increased DOX retention as compared to the DOX mono-delivery system (HA-SiLN/D). Conclusion: In vivo anticancer assays on the SGC7901/ADR tumor-bearing mice model also revealed significantly enhanced efficacy of HA-SiLN/QD than mono-delivery systems (HA-SiLN/Q and HA-SiLN/D). Keywords: gastric carcinoma, chemotherapy, quercetin, doxorubicin, co-deliveryFang JZhang SXue XZhu XSong SWang BJiang LQin MLiang HGao LDove Medical Pressarticlegastric carcinomachemotherapyquercetindoxorubicinco-deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5113-5126 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric carcinoma chemotherapy quercetin doxorubicin co-delivery Medicine (General) R5-920
spellingShingle	gastric carcinoma chemotherapy quercetin doxorubicin co-delivery Medicine (General) R5-920 Fang J Zhang S Xue X Zhu X Song S Wang B Jiang L Qin M Liang H Gao L Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy
description	Jian Fang,1,* Shangwu Zhang,2,* Xiaofeng Xue,3 Xinguo Zhu,3 Shiduo Song,3 Bin Wang,3 Linhua Jiang,3 Mingde Qin,4 Hansi Liang,4 Ling Gao3 1Department of General Surgery, Zhangjiagang Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, People’s Republic of China; 2Department of Emergency Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, People’s Republic of China; 3Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, People’s Republic of China; 4Department of General Surgery, The Stem Cell and Biomedical Material Key Laboratory of Jiangsu Province (The State Key Laboratory Incubation Base), Soochow University, Suzhou, Jiangsu Province, People’s Republic of China *These authors contributed equally to this work Background: Effective gastric carcinoma (GC) chemotherapy is subject to many in vitro and in vivo barriers, such as tumor microenvironment and multidrug resistance. Materials and methods: Herein, we developed a hyaluronic acid (HA)-modified silica nanoparticle (HA-SiLN/QD) co-delivering quercetin and doxorubicin (DOX) to enhance the efficacy of GC therapy (HA-SiLN/QD). The HA modification was done to recognize overexpressed CD44 receptors on GC cells and mediate selective tumor targeting. In parallel, quercetin delivery decreased the expression of Wnt16 and P-glycoprotein, thus remodeling the tumor microenvironment and reversed multidrug resistance to facilitate DOX activity. Results: Experimental results demonstrated that HA-SiLN/QD was nanoscaled particles with preferable stability and sustained release property. In vitro cell experiments on SGC7901/ADR cells showed selective uptake and increased DOX retention as compared to the DOX mono-delivery system (HA-SiLN/D). Conclusion: In vivo anticancer assays on the SGC7901/ADR tumor-bearing mice model also revealed significantly enhanced efficacy of HA-SiLN/QD than mono-delivery systems (HA-SiLN/Q and HA-SiLN/D). Keywords: gastric carcinoma, chemotherapy, quercetin, doxorubicin, co-delivery
format	article
author	Fang J Zhang S Xue X Zhu X Song S Wang B Jiang L Qin M Liang H Gao L
author_facet	Fang J Zhang S Xue X Zhu X Song S Wang B Jiang L Qin M Liang H Gao L
author_sort	Fang J
title	Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy
title_short	Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy
title_full	Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy
title_fullStr	Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy
title_full_unstemmed	Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy
title_sort	quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/6ce561a726ae4955bd358c35d4d6941c
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Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy

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