Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

Detection of LPS derived from Gram-negative bacteria by innate immune receptors is a critical step in the host response. Here Santos and colleagues show human GBP1 binds to LPS resulting in non-canonical inflammasome activation.

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Autores principales:	José Carlos Santos, Dave Boucher, Larisa Kapinos Schneider, Benjamin Demarco, Marisa Dilucca, Kateryna Shkarina, Rosalie Heilig, Kaiwen W. Chen, Roderick Y. H. Lim, Petr Broz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6cea1f719e794133aac06f44406b21f2
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spelling	oai:doaj.org-article:6cea1f719e794133aac06f44406b21f22021-12-02T17:45:00ZHuman GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria10.1038/s41467-020-16889-z2041-1723https://doaj.org/article/6cea1f719e794133aac06f44406b21f22020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16889-zhttps://doaj.org/toc/2041-1723Detection of LPS derived from Gram-negative bacteria by innate immune receptors is a critical step in the host response. Here Santos and colleagues show human GBP1 binds to LPS resulting in non-canonical inflammasome activation.José Carlos SantosDave BoucherLarisa Kapinos SchneiderBenjamin DemarcoMarisa DiluccaKateryna ShkarinaRosalie HeiligKaiwen W. ChenRoderick Y. H. LimPetr BrozNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q José Carlos Santos Dave Boucher Larisa Kapinos Schneider Benjamin Demarco Marisa Dilucca Kateryna Shkarina Rosalie Heilig Kaiwen W. Chen Roderick Y. H. Lim Petr Broz Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
description	Detection of LPS derived from Gram-negative bacteria by innate immune receptors is a critical step in the host response. Here Santos and colleagues show human GBP1 binds to LPS resulting in non-canonical inflammasome activation.
format	article
author	José Carlos Santos Dave Boucher Larisa Kapinos Schneider Benjamin Demarco Marisa Dilucca Kateryna Shkarina Rosalie Heilig Kaiwen W. Chen Roderick Y. H. Lim Petr Broz
author_facet	José Carlos Santos Dave Boucher Larisa Kapinos Schneider Benjamin Demarco Marisa Dilucca Kateryna Shkarina Rosalie Heilig Kaiwen W. Chen Roderick Y. H. Lim Petr Broz
author_sort	José Carlos Santos
title	Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
title_short	Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
title_full	Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
title_fullStr	Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
title_full_unstemmed	Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
title_sort	human gbp1 binds lps to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6cea1f719e794133aac06f44406b21f2
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Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

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