Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

Detection of LPS derived from Gram-negative bacteria by innate immune receptors is a critical step in the host response. Here Santos and colleagues show human GBP1 binds to LPS resulting in non-canonical inflammasome activation.

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Detalles Bibliográficos
Autores principales: José Carlos Santos, Dave Boucher, Larisa Kapinos Schneider, Benjamin Demarco, Marisa Dilucca, Kateryna Shkarina, Rosalie Heilig, Kaiwen W. Chen, Roderick Y. H. Lim, Petr Broz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/6cea1f719e794133aac06f44406b21f2
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