An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo

Several inherited human syndromes that severely affect organogenesis and other developmental processes are caused by mutations in replication stress response (RSR) genes. Although the molecular machinery of RSR is conserved, disease-causing mutations in RSR-genes may have distinct tissue-specific ou...

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Autores principales:	Gabriel E. Matos-Rodrigues, Rodrigo A. P. Martins
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	genome stability cell cycle DNA damage chekcpoint ATR organogenesis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6ceac0be911f4a9181217141128f9ca3
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id	oai:doaj.org-article:6ceac0be911f4a9181217141128f9ca3
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spelling	oai:doaj.org-article:6ceac0be911f4a9181217141128f9ca32021-11-04T06:47:05ZAn Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo2296-634X10.3389/fcell.2021.731308https://doaj.org/article/6ceac0be911f4a9181217141128f9ca32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.731308/fullhttps://doaj.org/toc/2296-634XSeveral inherited human syndromes that severely affect organogenesis and other developmental processes are caused by mutations in replication stress response (RSR) genes. Although the molecular machinery of RSR is conserved, disease-causing mutations in RSR-genes may have distinct tissue-specific outcomes, indicating that progenitor cells may differ in their responses to RSR inactivation. Therefore, understanding how different cell types respond to replication stress is crucial to uncover the mechanisms of RSR-related human syndromes. Here, we review the ocular manifestations in RSR-related human syndromes and summarize recent findings investigating the mechanisms of RSR during eye development in vivo. We highlight a remarkable heterogeneity of progenitor cells responses to RSR inactivation and discuss its implications for RSR-related human syndromes.Gabriel E. Matos-RodriguesRodrigo A. P. MartinsFrontiers Media S.A.articlegenome stabilitycell cycleDNA damagechekcpointATRorganogenesisBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	genome stability cell cycle DNA damage chekcpoint ATR organogenesis Biology (General) QH301-705.5
spellingShingle	genome stability cell cycle DNA damage chekcpoint ATR organogenesis Biology (General) QH301-705.5 Gabriel E. Matos-Rodrigues Rodrigo A. P. Martins An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo
description	Several inherited human syndromes that severely affect organogenesis and other developmental processes are caused by mutations in replication stress response (RSR) genes. Although the molecular machinery of RSR is conserved, disease-causing mutations in RSR-genes may have distinct tissue-specific outcomes, indicating that progenitor cells may differ in their responses to RSR inactivation. Therefore, understanding how different cell types respond to replication stress is crucial to uncover the mechanisms of RSR-related human syndromes. Here, we review the ocular manifestations in RSR-related human syndromes and summarize recent findings investigating the mechanisms of RSR during eye development in vivo. We highlight a remarkable heterogeneity of progenitor cells responses to RSR inactivation and discuss its implications for RSR-related human syndromes.
format	article
author	Gabriel E. Matos-Rodrigues Rodrigo A. P. Martins
author_facet	Gabriel E. Matos-Rodrigues Rodrigo A. P. Martins
author_sort	Gabriel E. Matos-Rodrigues
title	An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo
title_short	An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo
title_full	An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo
title_fullStr	An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo
title_full_unstemmed	An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo
title_sort	eye in the replication stress response: lessons from tissue-specific studies in vivo
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6ceac0be911f4a9181217141128f9ca3
work_keys_str_mv	AT gabrielematosrodrigues aneyeinthereplicationstressresponselessonsfromtissuespecificstudiesinvivo AT rodrigoapmartins aneyeinthereplicationstressresponselessonsfromtissuespecificstudiesinvivo AT gabrielematosrodrigues eyeinthereplicationstressresponselessonsfromtissuespecificstudiesinvivo AT rodrigoapmartins eyeinthereplicationstressresponselessonsfromtissuespecificstudiesinvivo
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An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo

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