Prognostic value of cardiac biomarkers in COVID-19 infection

Abstract Multiple Biomarkers have recently been shown to be elevated in COVID-19, a respiratory infection with multi-organ dysfunction; however, information regarding the prognostic value of cardiac biomarkers as it relates to disease severity and cardiac injury are inconsistent. The goal of this me...

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Autores principales:	Aakash Sheth, Malak Modi, Desiree’ Dawson, Paari Dominic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6cebe0884c9b4e399a5de50df07304c1
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spelling	oai:doaj.org-article:6cebe0884c9b4e399a5de50df07304c12021-12-02T13:19:22ZPrognostic value of cardiac biomarkers in COVID-19 infection10.1038/s41598-021-84643-62045-2322https://doaj.org/article/6cebe0884c9b4e399a5de50df07304c12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84643-6https://doaj.org/toc/2045-2322Abstract Multiple Biomarkers have recently been shown to be elevated in COVID-19, a respiratory infection with multi-organ dysfunction; however, information regarding the prognostic value of cardiac biomarkers as it relates to disease severity and cardiac injury are inconsistent. The goal of this meta-analysis was to summarize the evidence regarding the prognostic relevance of cardiac biomarkers from data available in published reports. PubMed, Embase and Web of Science were searched from inception through April 2020 for studies comparing median values of cardiac biomarkers in critically ill versus non-critically ill COVID-19 patients, or patients who died versus those who survived. The weighted mean differences (WMD) and 95% confidence interval (CI) between the groups were calculated for each study and combined using a random effects meta-analysis model. The odds ratio (OR) for mortality based on cardiac injury was combined from studies reporting it. Troponin levels were significantly higher in COVID-19 patients who died or were critically ill versus those who were alive or not critically ill (WMD 0.57, 95% CI 0.43–0.70, p < 0.001). Additionally, BNP levels were also significantly higher in patients who died or were critically ill (WMD 0.45, 95% CI − 0.21–0.69, p < 0.001). Cardiac injury was independently associated with significantly increased odds of mortality (OR 6.641, 95% CI 1.26–35.1, p = 0.03). A significant difference in levels of D-dimer was seen in those who died or were critically ill. CK levels were only significantly higher in those who died versus those who were alive (WMD 0.79, 95% CI 0.25–1.33, p = 0.004). Cardiac biomarkers add prognostic value to the determination of the severity of COVID-19 and can predict mortality.Aakash ShethMalak ModiDesiree’ DawsonPaari DominicNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aakash Sheth Malak Modi Desiree’ Dawson Paari Dominic Prognostic value of cardiac biomarkers in COVID-19 infection
description	Abstract Multiple Biomarkers have recently been shown to be elevated in COVID-19, a respiratory infection with multi-organ dysfunction; however, information regarding the prognostic value of cardiac biomarkers as it relates to disease severity and cardiac injury are inconsistent. The goal of this meta-analysis was to summarize the evidence regarding the prognostic relevance of cardiac biomarkers from data available in published reports. PubMed, Embase and Web of Science were searched from inception through April 2020 for studies comparing median values of cardiac biomarkers in critically ill versus non-critically ill COVID-19 patients, or patients who died versus those who survived. The weighted mean differences (WMD) and 95% confidence interval (CI) between the groups were calculated for each study and combined using a random effects meta-analysis model. The odds ratio (OR) for mortality based on cardiac injury was combined from studies reporting it. Troponin levels were significantly higher in COVID-19 patients who died or were critically ill versus those who were alive or not critically ill (WMD 0.57, 95% CI 0.43–0.70, p < 0.001). Additionally, BNP levels were also significantly higher in patients who died or were critically ill (WMD 0.45, 95% CI − 0.21–0.69, p < 0.001). Cardiac injury was independently associated with significantly increased odds of mortality (OR 6.641, 95% CI 1.26–35.1, p = 0.03). A significant difference in levels of D-dimer was seen in those who died or were critically ill. CK levels were only significantly higher in those who died versus those who were alive (WMD 0.79, 95% CI 0.25–1.33, p = 0.004). Cardiac biomarkers add prognostic value to the determination of the severity of COVID-19 and can predict mortality.
format	article
author	Aakash Sheth Malak Modi Desiree’ Dawson Paari Dominic
author_facet	Aakash Sheth Malak Modi Desiree’ Dawson Paari Dominic
author_sort	Aakash Sheth
title	Prognostic value of cardiac biomarkers in COVID-19 infection
title_short	Prognostic value of cardiac biomarkers in COVID-19 infection
title_full	Prognostic value of cardiac biomarkers in COVID-19 infection
title_fullStr	Prognostic value of cardiac biomarkers in COVID-19 infection
title_full_unstemmed	Prognostic value of cardiac biomarkers in COVID-19 infection
title_sort	prognostic value of cardiac biomarkers in covid-19 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6cebe0884c9b4e399a5de50df07304c1
work_keys_str_mv	AT aakashsheth prognosticvalueofcardiacbiomarkersincovid19infection AT malakmodi prognosticvalueofcardiacbiomarkersincovid19infection AT desireedawson prognosticvalueofcardiacbiomarkersincovid19infection AT paaridominic prognosticvalueofcardiacbiomarkersincovid19infection
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Prognostic value of cardiac biomarkers in COVID-19 infection

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