Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells

Ye Wang,1,2,* Xiao-Yuan Zi,1,* Juan Su,1 Hong-Xia Zhang,1 Xin-Rong Zhang,3 Hai-Ying Zhu,1 Jian-Xiu Li,1 Meng Yin,3 Feng Yang,3 Yi-Ping Hu,11Department of Cell Biology, 2School of Clinical Medicine, 3Department of Pharmaceuticals, Second Military Medical University, Shanghai, People&#39;s Rep...

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Autores principales:	Wang Y, Zi XY, Su J, Zhang HX, Zhang XR, Zhu HY, Li JX, Yin M, Yang F, Hu YP.
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6cec2f896bb14f7c8c264b2f670305c5
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spelling	oai:doaj.org-article:6cec2f896bb14f7c8c264b2f670305c52021-12-02T06:26:20ZCuprous oxide nanoparticles selectively induce apoptosis of tumor cells1176-91141178-2013https://doaj.org/article/6cec2f896bb14f7c8c264b2f670305c52012-05-01T00:00:00Zhttp://www.dovepress.com/cuprous-oxide-nanoparticles-selectively-induce-apoptosis-of-tumor-cell-a9974https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ye Wang,1,2,* Xiao-Yuan Zi,1,* Juan Su,1 Hong-Xia Zhang,1 Xin-Rong Zhang,3 Hai-Ying Zhu,1 Jian-Xiu Li,1 Meng Yin,3 Feng Yang,3 Yi-Ping Hu,11Department of Cell Biology, 2School of Clinical Medicine, 3Department of Pharmaceuticals, Second Military Medical University, Shanghai, People&#39;s Republic of China*Authors contributed equally.Abstract: In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects. Cuprous oxide nanoparticles (CONPs) can selectively induce apoptosis and suppress the proliferation of tumor cells, showing great potential as a clinical cancer therapy. Treatment with CONPs caused a G1/G0 cell cycle arrest in tumor cells. Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis. CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells. Our results demonstrate that CONPs have selective cytotoxicity towards tumor cells, and indicate that CONPs might be a potential nanomedicine for cancer therapy.Keywords: nanomedicine, selective cytotoxicity, apoptosis, cell cycle arrest, mitochondrion-targeted nanomaterialsWang YZi XYSu JZhang HXZhang XRZhu HYLi JXYin MYang FHu YP.Dove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 2641-2652 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wang Y Zi XY Su J Zhang HX Zhang XR Zhu HY Li JX Yin M Yang F Hu YP. Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells
description	Ye Wang,1,2,* Xiao-Yuan Zi,1,* Juan Su,1 Hong-Xia Zhang,1 Xin-Rong Zhang,3 Hai-Ying Zhu,1 Jian-Xiu Li,1 Meng Yin,3 Feng Yang,3 Yi-Ping Hu,11Department of Cell Biology, 2School of Clinical Medicine, 3Department of Pharmaceuticals, Second Military Medical University, Shanghai, People&#39;s Republic of China*Authors contributed equally.Abstract: In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects. Cuprous oxide nanoparticles (CONPs) can selectively induce apoptosis and suppress the proliferation of tumor cells, showing great potential as a clinical cancer therapy. Treatment with CONPs caused a G1/G0 cell cycle arrest in tumor cells. Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis. CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells. Our results demonstrate that CONPs have selective cytotoxicity towards tumor cells, and indicate that CONPs might be a potential nanomedicine for cancer therapy.Keywords: nanomedicine, selective cytotoxicity, apoptosis, cell cycle arrest, mitochondrion-targeted nanomaterials
format	article
author	Wang Y Zi XY Su J Zhang HX Zhang XR Zhu HY Li JX Yin M Yang F Hu YP.
author_facet	Wang Y Zi XY Su J Zhang HX Zhang XR Zhu HY Li JX Yin M Yang F Hu YP.
author_sort	Wang Y
title	Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells
title_short	Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells
title_full	Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells
title_fullStr	Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells
title_full_unstemmed	Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells
title_sort	cuprous oxide nanoparticles selectively induce apoptosis of tumor cells
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/6cec2f896bb14f7c8c264b2f670305c5
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Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells

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