Ameliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis

Coriander is a commonly used vegetable, spice, and folk medicine, possessing both nutritional and medicinal properties. Up to two-thirds of patients with rheumatoid arthritis (RA) exhibit loss of body mass, predominately skeletal muscle mass, a process called rheumatoid cachexia, and this has major...

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Autores principales:	Huijuan Jia, Ya Wen, Wanping Aw, Kenji Saito, Hisanori Kato
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	coriander rheumatoid arthritis precachexia gastrocnemius skeletal muscle proteomics Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/6ceca5b835af429794be8789fcb5728f
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spelling	oai:doaj.org-article:6ceca5b835af429794be8789fcb5728f2021-11-25T18:36:18ZAmeliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis10.3390/nu131140412072-6643https://doaj.org/article/6ceca5b835af429794be8789fcb5728f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4041https://doaj.org/toc/2072-6643Coriander is a commonly used vegetable, spice, and folk medicine, possessing both nutritional and medicinal properties. Up to two-thirds of patients with rheumatoid arthritis (RA) exhibit loss of body mass, predominately skeletal muscle mass, a process called rheumatoid cachexia, and this has major effects of the quality of life of patients. Owing to a lack of effective treatments, the initial stage of cachexia has been proposed as an important period for prevention and decreasing pathogenesis. In the current study, we found that cachexia-like molecular disorders and muscle weight loss were in progress in gastrocnemius muscle after only 5 days of RA induction in rats, although rheumatoid cachexia symptoms have been reported occurring approximately 45 days after RA induction. Oral administration of coriander slightly restored muscle loss. Moreover, iTRAQ-based quantitative proteomics revealed that coriander treatment could partially restore the molecular derangements induced by RA, including impaired carbon metabolism, deteriorated mitochondrial function (tricarboxylic acid cycle and oxidative phosphorylation), and myofiber-type alterations. Therefore, coriander could be a promising functional food and/or complementary therapy for patients with RA against cachexia.Huijuan JiaYa WenWanping AwKenji SaitoHisanori KatoMDPI AGarticlecorianderrheumatoid arthritisprecachexiagastrocnemius skeletal muscleproteomicsNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4041, p 4041 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coriander rheumatoid arthritis precachexia gastrocnemius skeletal muscle proteomics Nutrition. Foods and food supply TX341-641
spellingShingle	coriander rheumatoid arthritis precachexia gastrocnemius skeletal muscle proteomics Nutrition. Foods and food supply TX341-641 Huijuan Jia Ya Wen Wanping Aw Kenji Saito Hisanori Kato Ameliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis
description	Coriander is a commonly used vegetable, spice, and folk medicine, possessing both nutritional and medicinal properties. Up to two-thirds of patients with rheumatoid arthritis (RA) exhibit loss of body mass, predominately skeletal muscle mass, a process called rheumatoid cachexia, and this has major effects of the quality of life of patients. Owing to a lack of effective treatments, the initial stage of cachexia has been proposed as an important period for prevention and decreasing pathogenesis. In the current study, we found that cachexia-like molecular disorders and muscle weight loss were in progress in gastrocnemius muscle after only 5 days of RA induction in rats, although rheumatoid cachexia symptoms have been reported occurring approximately 45 days after RA induction. Oral administration of coriander slightly restored muscle loss. Moreover, iTRAQ-based quantitative proteomics revealed that coriander treatment could partially restore the molecular derangements induced by RA, including impaired carbon metabolism, deteriorated mitochondrial function (tricarboxylic acid cycle and oxidative phosphorylation), and myofiber-type alterations. Therefore, coriander could be a promising functional food and/or complementary therapy for patients with RA against cachexia.
format	article
author	Huijuan Jia Ya Wen Wanping Aw Kenji Saito Hisanori Kato
author_facet	Huijuan Jia Ya Wen Wanping Aw Kenji Saito Hisanori Kato
author_sort	Huijuan Jia
title	Ameliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis
title_short	Ameliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis
title_full	Ameliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis
title_fullStr	Ameliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis
title_full_unstemmed	Ameliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis
title_sort	ameliorating effects of coriander on gastrocnemius muscles undergoing precachexia in a rat model of rheumatoid arthritis: a proteomics analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6ceca5b835af429794be8789fcb5728f
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Ameliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis

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