Advances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing

Ming Zhao, Jihong Shi, Weixia Cai, Kaituo Liu, Kuo Shen, Zichao Li, Yunchuan Wang, Dahai Hu Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shannxi, 710032, People’s Republic of ChinaCorrespondence: Yunchuan Wang; Dahai HuDep...

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Autores principales:	Zhao M, Shi J, Cai W, Liu K, Shen K, Li Z, Wang Y, Hu D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	graphene carbon nanomaterials mesenchymal stem cells exosomes wound healing Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6ceca614512b448cbb9b09f690868985
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spelling	oai:doaj.org-article:6ceca614512b448cbb9b09f6908689852021-12-02T14:52:52ZAdvances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing1178-2013https://doaj.org/article/6ceca614512b448cbb9b09f6908689852021-04-01T00:00:00Zhttps://www.dovepress.com/advances-on-graphene-based-nanomaterials-and-mesenchymal-stem-cell-der-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ming Zhao, Jihong Shi, Weixia Cai, Kaituo Liu, Kuo Shen, Zichao Li, Yunchuan Wang, Dahai Hu Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shannxi, 710032, People’s Republic of ChinaCorrespondence: Yunchuan Wang; Dahai HuDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shannxi, 710032, People’s Republic of ChinaTel +86 29-84775293; +86 29-84775298Email wangyunchuan@fmmu.edu.cn; hudahaidoc@163.comAbstract: Graphene is a new type of carbon nanomaterial discovered after fullerene and carbon nanotube. Due to the excellent biological properties such as biocompatibility, cell proliferation stimulating, and antibacterial properties, graphene and its derivatives have become emerging candidates for the development of novel cutaneous wound dressings and composite scaffolds. On the other hand, pre-clinical research on exosomes derived from mesenchymal stem cells (MSC-Exos) has been intensified for cell-free treatment in wound healing and cutaneous regeneration, via ameliorating the damaged microenvironment of the wound site. Here, we provide a comprehensive understanding of the latest studies and observations on the various effects of graphene-based nanomaterials (GBNs) and MSC-Exos during the cutaneous wound repair process, as well as the putative mechanisms thereof. In addition, we propose the possible forward directions of GBNs and MSC-Exos applications, expecting to promote the clinical transformation.Keywords: graphene, carbon nanomaterials, mesenchymal stem cells, exosomes, wound healingZhao MShi JCai WLiu KShen KLi ZWang YHu DDove Medical Pressarticlegraphenecarbon nanomaterialsmesenchymal stem cellsexosomeswound healingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 2647-2665 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	graphene carbon nanomaterials mesenchymal stem cells exosomes wound healing Medicine (General) R5-920
spellingShingle	graphene carbon nanomaterials mesenchymal stem cells exosomes wound healing Medicine (General) R5-920 Zhao M Shi J Cai W Liu K Shen K Li Z Wang Y Hu D Advances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing
description	Ming Zhao, Jihong Shi, Weixia Cai, Kaituo Liu, Kuo Shen, Zichao Li, Yunchuan Wang, Dahai Hu Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shannxi, 710032, People’s Republic of ChinaCorrespondence: Yunchuan Wang; Dahai HuDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shannxi, 710032, People’s Republic of ChinaTel +86 29-84775293; +86 29-84775298Email wangyunchuan@fmmu.edu.cn; hudahaidoc@163.comAbstract: Graphene is a new type of carbon nanomaterial discovered after fullerene and carbon nanotube. Due to the excellent biological properties such as biocompatibility, cell proliferation stimulating, and antibacterial properties, graphene and its derivatives have become emerging candidates for the development of novel cutaneous wound dressings and composite scaffolds. On the other hand, pre-clinical research on exosomes derived from mesenchymal stem cells (MSC-Exos) has been intensified for cell-free treatment in wound healing and cutaneous regeneration, via ameliorating the damaged microenvironment of the wound site. Here, we provide a comprehensive understanding of the latest studies and observations on the various effects of graphene-based nanomaterials (GBNs) and MSC-Exos during the cutaneous wound repair process, as well as the putative mechanisms thereof. In addition, we propose the possible forward directions of GBNs and MSC-Exos applications, expecting to promote the clinical transformation.Keywords: graphene, carbon nanomaterials, mesenchymal stem cells, exosomes, wound healing
format	article
author	Zhao M Shi J Cai W Liu K Shen K Li Z Wang Y Hu D
author_facet	Zhao M Shi J Cai W Liu K Shen K Li Z Wang Y Hu D
author_sort	Zhao M
title	Advances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing
title_short	Advances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing
title_full	Advances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing
title_fullStr	Advances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing
title_full_unstemmed	Advances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing
title_sort	advances on graphene-based nanomaterials and mesenchymal stem cell-derived exosomes applied in cutaneous wound healing
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6ceca614512b448cbb9b09f690868985
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Advances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing

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