Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement

Abstract The chelating gadolinium-complex is routinely used as magnetic resonance imaging (MRI) -contrast enhancer. However, several safety issues have recently been reported by FDA and PRAC. There is an urgent need for the next generation of safer MRI-contrast enhancers, with improved local contras...

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Autores principales:	Peter Eriksson, Alexey A. Tal, Andreas Skallberg, Caroline Brommesson, Zhangjun Hu, Robert D. Boyd, Weine Olovsson, Neal Fairley, Igor A. Abrikosov, Xuanjun Zhang, Kajsa Uvdal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6cef5a9dc92a4ef697517e7ebe6f4d3c
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spelling	oai:doaj.org-article:6cef5a9dc92a4ef697517e7ebe6f4d3c2021-12-02T12:32:35ZCerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement10.1038/s41598-018-25390-z2045-2322https://doaj.org/article/6cef5a9dc92a4ef697517e7ebe6f4d3c2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25390-zhttps://doaj.org/toc/2045-2322Abstract The chelating gadolinium-complex is routinely used as magnetic resonance imaging (MRI) -contrast enhancer. However, several safety issues have recently been reported by FDA and PRAC. There is an urgent need for the next generation of safer MRI-contrast enhancers, with improved local contrast and targeting capabilities. Cerium oxide nanoparticles (CeNPs) are designed with fractions of up to 50% gadolinium to utilize the superior MRI-contrast properties of gadolinium. CeNPs are well-tolerated in vivo and have redox properties making them suitable for biomedical applications, for example scavenging purposes on the tissue- and cellular level and during tumor treatment to reduce in vivo inflammatory processes. Our near edge X-ray absorption fine structure (NEXAFS) studies show that implementation of gadolinium changes the initial co-existence of oxidation states Ce3+ and Ce4+ of cerium, thereby affecting the scavenging properties of the nanoparticles. Based on ab initio electronic structure calculations, we describe the most prominent spectral features for the respective oxidation states. The as-prepared gadolinium-implemented CeNPs are 3–5 nm in size, have r1-relaxivities between 7–13 mM−1 s−1 and show clear antioxidative properties, all of which means they are promising theranostic agents for use in future biomedical applications.Peter ErikssonAlexey A. TalAndreas SkallbergCaroline BrommessonZhangjun HuRobert D. BoydWeine OlovssonNeal FairleyIgor A. AbrikosovXuanjun ZhangKajsa UvdalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter Eriksson Alexey A. Tal Andreas Skallberg Caroline Brommesson Zhangjun Hu Robert D. Boyd Weine Olovsson Neal Fairley Igor A. Abrikosov Xuanjun Zhang Kajsa Uvdal Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement
description	Abstract The chelating gadolinium-complex is routinely used as magnetic resonance imaging (MRI) -contrast enhancer. However, several safety issues have recently been reported by FDA and PRAC. There is an urgent need for the next generation of safer MRI-contrast enhancers, with improved local contrast and targeting capabilities. Cerium oxide nanoparticles (CeNPs) are designed with fractions of up to 50% gadolinium to utilize the superior MRI-contrast properties of gadolinium. CeNPs are well-tolerated in vivo and have redox properties making them suitable for biomedical applications, for example scavenging purposes on the tissue- and cellular level and during tumor treatment to reduce in vivo inflammatory processes. Our near edge X-ray absorption fine structure (NEXAFS) studies show that implementation of gadolinium changes the initial co-existence of oxidation states Ce3+ and Ce4+ of cerium, thereby affecting the scavenging properties of the nanoparticles. Based on ab initio electronic structure calculations, we describe the most prominent spectral features for the respective oxidation states. The as-prepared gadolinium-implemented CeNPs are 3–5 nm in size, have r1-relaxivities between 7–13 mM−1 s−1 and show clear antioxidative properties, all of which means they are promising theranostic agents for use in future biomedical applications.
format	article
author	Peter Eriksson Alexey A. Tal Andreas Skallberg Caroline Brommesson Zhangjun Hu Robert D. Boyd Weine Olovsson Neal Fairley Igor A. Abrikosov Xuanjun Zhang Kajsa Uvdal
author_facet	Peter Eriksson Alexey A. Tal Andreas Skallberg Caroline Brommesson Zhangjun Hu Robert D. Boyd Weine Olovsson Neal Fairley Igor A. Abrikosov Xuanjun Zhang Kajsa Uvdal
author_sort	Peter Eriksson
title	Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement
title_short	Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement
title_full	Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement
title_fullStr	Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement
title_full_unstemmed	Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement
title_sort	cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for mri contrast enhancement
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6cef5a9dc92a4ef697517e7ebe6f4d3c
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Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement

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