Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling

Core clock genes, such asBmal1, are expressed in astrocytes, but their contribution to the timekeeping system is unknown. Barca-Mayo et al. report that deletion of Bmal1in Glast+ astrocytes alters the neuronal clock through GABA signalling, leading to abnormal circadian locomotor behaviour and impai...

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Autores principales:	Olga Barca-Mayo, Meritxell Pons-Espinal, Philipp Follert, Andrea Armirotti, Luca Berdondini, Davide De Pietri Tonelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6cf02a69d9e34b0882583d40e57b466b
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spelling	oai:doaj.org-article:6cf02a69d9e34b0882583d40e57b466b2021-12-02T14:42:10ZAstrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling10.1038/ncomms143362041-1723https://doaj.org/article/6cf02a69d9e34b0882583d40e57b466b2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14336https://doaj.org/toc/2041-1723Core clock genes, such asBmal1, are expressed in astrocytes, but their contribution to the timekeeping system is unknown. Barca-Mayo et al. report that deletion of Bmal1in Glast+ astrocytes alters the neuronal clock through GABA signalling, leading to abnormal circadian locomotor behaviour and impaired cognition in mice.Olga Barca-MayoMeritxell Pons-EspinalPhilipp FollertAndrea ArmirottiLuca BerdondiniDavide De Pietri TonelliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Olga Barca-Mayo Meritxell Pons-Espinal Philipp Follert Andrea Armirotti Luca Berdondini Davide De Pietri Tonelli Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling
description	Core clock genes, such asBmal1, are expressed in astrocytes, but their contribution to the timekeeping system is unknown. Barca-Mayo et al. report that deletion of Bmal1in Glast+ astrocytes alters the neuronal clock through GABA signalling, leading to abnormal circadian locomotor behaviour and impaired cognition in mice.
format	article
author	Olga Barca-Mayo Meritxell Pons-Espinal Philipp Follert Andrea Armirotti Luca Berdondini Davide De Pietri Tonelli
author_facet	Olga Barca-Mayo Meritxell Pons-Espinal Philipp Follert Andrea Armirotti Luca Berdondini Davide De Pietri Tonelli
author_sort	Olga Barca-Mayo
title	Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling
title_short	Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling
title_full	Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling
title_fullStr	Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling
title_full_unstemmed	Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling
title_sort	astrocyte deletion of bmal1 alters daily locomotor activity and cognitive functions via gaba signalling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6cf02a69d9e34b0882583d40e57b466b
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Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling

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