Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling

Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling

Core clock genes, such asBmal1, are expressed in astrocytes, but their contribution to the timekeeping system is unknown. Barca-Mayo et al. report that deletion of Bmal1in Glast+ astrocytes alters the neuronal clock through GABA signalling, leading to abnormal circadian locomotor behaviour and impai...

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Autores principales: Olga Barca-Mayo, Meritxell Pons-Espinal, Philipp Follert, Andrea Armirotti, Luca Berdondini, Davide De Pietri Tonelli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6cf02a69d9e34b0882583d40e57b466b
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