Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts

Rui Fang,1,2 Shupei Qiao,1 Yi Liu,1 Qingyuan Meng,3 Xiongbiao Chen,2,4 Bing Song,5 Xiaolu Hou,6 Weiming Tian1 1Bio-X Center, School of Life Science and Technology, Harbin Institute of Technology, Harbin, People’s Republic of China; 2Division of Biomedical Engineering, University...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fang R, Qiao S, Liu Y, Meng Q, Chen X, Song B, Hou X, Tian W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6cf0e4601f4f49e7bc31b43755c9cc67
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6cf0e4601f4f49e7bc31b43755c9cc67
record_format	dspace
spelling	oai:doaj.org-article:6cf0e4601f4f49e7bc31b43755c9cc672021-12-02T02:08:31ZSustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts1178-2013https://doaj.org/article/6cf0e4601f4f49e7bc31b43755c9cc672015-07-01T00:00:00Zhttp://www.dovepress.com/sustained-co-delivery-of-bio-and-igf-1-by-a-novel-hybrid-hydrogel-syst-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Rui Fang,1,2 Shupei Qiao,1 Yi Liu,1 Qingyuan Meng,3 Xiongbiao Chen,2,4 Bing Song,5 Xiaolu Hou,6 Weiming Tian1 1Bio-X Center, School of Life Science and Technology, Harbin Institute of Technology, Harbin, People’s Republic of China; 2Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada; 3State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People’s Republic of China; 4Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada; 5College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK; 6Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China Abstract: Dedifferentiation and proliferation of endogenous cardiomyocytes in situ can effectively improve cardiac repair following myocardial infarction (MI). 6-Bromoindirubin-3-oxime (BIO) and insulin-like growth factor 1 (IGF-1) are two potent factors that promote cardiomyocyte survival and proliferation. However, their delivery for sustained release in MI-affected areas has proved to be challenging. In the current research, we present a study on the sustained co-delivery of BIO and IGF-1 in a hybrid hydrogel system to simulate endogenous cardiac repair in an MI rat model. Both BIO and IGF-1 were efficiently encapsulated in gelatin nanoparticles, which were later cross-linked with the oxidized alginate to form a novel hybrid hydrogel system. The in vivo results indicated that the hybrid system could enhance the proliferation of cardiomyocytes in situ and could promote revascularization around the MI sites, allowing improved cardiac function. Taken together, we concluded that the hybrid hydrogel system can co-deliver BIO and IGF-1 to areas of MI and thus improve cardiac function by promoting the proliferation of cardiomyocytes and revascularization. Keywords: myocardial infarction, gelatin nanoparticle, cardiomyocyte proliferation, injectable hydrogelFang RQiao SLiu YMeng QChen XSong BHou XTian WDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4691-4703 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Fang R Qiao S Liu Y Meng Q Chen X Song B Hou X Tian W Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts
description	Rui Fang,1,2 Shupei Qiao,1 Yi Liu,1 Qingyuan Meng,3 Xiongbiao Chen,2,4 Bing Song,5 Xiaolu Hou,6 Weiming Tian1 1Bio-X Center, School of Life Science and Technology, Harbin Institute of Technology, Harbin, People’s Republic of China; 2Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada; 3State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People’s Republic of China; 4Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada; 5College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK; 6Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China Abstract: Dedifferentiation and proliferation of endogenous cardiomyocytes in situ can effectively improve cardiac repair following myocardial infarction (MI). 6-Bromoindirubin-3-oxime (BIO) and insulin-like growth factor 1 (IGF-1) are two potent factors that promote cardiomyocyte survival and proliferation. However, their delivery for sustained release in MI-affected areas has proved to be challenging. In the current research, we present a study on the sustained co-delivery of BIO and IGF-1 in a hybrid hydrogel system to simulate endogenous cardiac repair in an MI rat model. Both BIO and IGF-1 were efficiently encapsulated in gelatin nanoparticles, which were later cross-linked with the oxidized alginate to form a novel hybrid hydrogel system. The in vivo results indicated that the hybrid system could enhance the proliferation of cardiomyocytes in situ and could promote revascularization around the MI sites, allowing improved cardiac function. Taken together, we concluded that the hybrid hydrogel system can co-deliver BIO and IGF-1 to areas of MI and thus improve cardiac function by promoting the proliferation of cardiomyocytes and revascularization. Keywords: myocardial infarction, gelatin nanoparticle, cardiomyocyte proliferation, injectable hydrogel
format	article
author	Fang R Qiao S Liu Y Meng Q Chen X Song B Hou X Tian W
author_facet	Fang R Qiao S Liu Y Meng Q Chen X Song B Hou X Tian W
author_sort	Fang R
title	Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts
title_short	Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts
title_full	Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts
title_fullStr	Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts
title_full_unstemmed	Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts
title_sort	sustained co-delivery of bio and igf-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/6cf0e4601f4f49e7bc31b43755c9cc67
work_keys_str_mv	AT fangr sustainedcodeliveryofbioandigf1byanovelhybridhydrogelsystemtostimulateendogenouscardiacrepairinmyocardialinfarctedrathearts AT qiaos sustainedcodeliveryofbioandigf1byanovelhybridhydrogelsystemtostimulateendogenouscardiacrepairinmyocardialinfarctedrathearts AT liuy sustainedcodeliveryofbioandigf1byanovelhybridhydrogelsystemtostimulateendogenouscardiacrepairinmyocardialinfarctedrathearts AT mengq sustainedcodeliveryofbioandigf1byanovelhybridhydrogelsystemtostimulateendogenouscardiacrepairinmyocardialinfarctedrathearts AT chenx sustainedcodeliveryofbioandigf1byanovelhybridhydrogelsystemtostimulateendogenouscardiacrepairinmyocardialinfarctedrathearts AT songb sustainedcodeliveryofbioandigf1byanovelhybridhydrogelsystemtostimulateendogenouscardiacrepairinmyocardialinfarctedrathearts AT houx sustainedcodeliveryofbioandigf1byanovelhybridhydrogelsystemtostimulateendogenouscardiacrepairinmyocardialinfarctedrathearts AT tianw sustainedcodeliveryofbioandigf1byanovelhybridhydrogelsystemtostimulateendogenouscardiacrepairinmyocardialinfarctedrathearts
_version_	1718402654019780608

Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts

Ejemplares similares