TNFα drives mitochondrial stress in POMC neurons in obesity

Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induces mitochondrial stress in satiety-promoting POMC ne...

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Autores principales:	Chun-Xia Yi, Marc Walter, Yuanqing Gao, Soledad Pitra, Beata Legutko, Stefanie Kälin, Clarita Layritz, Cristina García-Cáceres, Maximilian Bielohuby, Martin Bidlingmaier, Stephen C. Woods, Alexander Ghanem, Karl-Klaus Conzelmann, Javier E. Stern, Martin Jastroch, Matthias H. Tschöp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6cf55e31e14747279bd3ace341933215
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spelling	oai:doaj.org-article:6cf55e31e14747279bd3ace3419332152021-12-02T14:40:24ZTNFα drives mitochondrial stress in POMC neurons in obesity10.1038/ncomms151432041-1723https://doaj.org/article/6cf55e31e14747279bd3ace3419332152017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15143https://doaj.org/toc/2041-1723Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induces mitochondrial stress in satiety-promoting POMC neurons.Chun-Xia YiMarc WalterYuanqing GaoSoledad PitraBeata LegutkoStefanie KälinClarita LayritzCristina García-CáceresMaximilian BielohubyMartin BidlingmaierStephen C. WoodsAlexander GhanemKarl-Klaus ConzelmannJavier E. SternMartin JastrochMatthias H. TschöpNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chun-Xia Yi Marc Walter Yuanqing Gao Soledad Pitra Beata Legutko Stefanie Kälin Clarita Layritz Cristina García-Cáceres Maximilian Bielohuby Martin Bidlingmaier Stephen C. Woods Alexander Ghanem Karl-Klaus Conzelmann Javier E. Stern Martin Jastroch Matthias H. Tschöp TNFα drives mitochondrial stress in POMC neurons in obesity
description	Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induces mitochondrial stress in satiety-promoting POMC neurons.
format	article
author	Chun-Xia Yi Marc Walter Yuanqing Gao Soledad Pitra Beata Legutko Stefanie Kälin Clarita Layritz Cristina García-Cáceres Maximilian Bielohuby Martin Bidlingmaier Stephen C. Woods Alexander Ghanem Karl-Klaus Conzelmann Javier E. Stern Martin Jastroch Matthias H. Tschöp
author_facet	Chun-Xia Yi Marc Walter Yuanqing Gao Soledad Pitra Beata Legutko Stefanie Kälin Clarita Layritz Cristina García-Cáceres Maximilian Bielohuby Martin Bidlingmaier Stephen C. Woods Alexander Ghanem Karl-Klaus Conzelmann Javier E. Stern Martin Jastroch Matthias H. Tschöp
author_sort	Chun-Xia Yi
title	TNFα drives mitochondrial stress in POMC neurons in obesity
title_short	TNFα drives mitochondrial stress in POMC neurons in obesity
title_full	TNFα drives mitochondrial stress in POMC neurons in obesity
title_fullStr	TNFα drives mitochondrial stress in POMC neurons in obesity
title_full_unstemmed	TNFα drives mitochondrial stress in POMC neurons in obesity
title_sort	tnfα drives mitochondrial stress in pomc neurons in obesity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6cf55e31e14747279bd3ace341933215
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TNFα drives mitochondrial stress in POMC neurons in obesity

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