Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression
Abstract Late-life depression (LLD) is associated with a risk of developing Alzheimer’s disease (AD). However, the role of AD-pathophysiology in LLD, and its association with clinical symptoms and cognitive function are elusive. In this study, one hundred subjects underwent amyloid positron emission...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/6cf5814ddb3f4fdf95d048dcf2f41a10 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:6cf5814ddb3f4fdf95d048dcf2f41a10 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:6cf5814ddb3f4fdf95d048dcf2f41a102021-12-02T17:06:24ZLower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression10.1038/s41598-021-95206-02045-2322https://doaj.org/article/6cf5814ddb3f4fdf95d048dcf2f41a102021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95206-0https://doaj.org/toc/2045-2322Abstract Late-life depression (LLD) is associated with a risk of developing Alzheimer’s disease (AD). However, the role of AD-pathophysiology in LLD, and its association with clinical symptoms and cognitive function are elusive. In this study, one hundred subjects underwent amyloid positron emission tomography (PET) imaging with [18F]-flutemetamol and structural MRI: 48 severely depressed elderly subjects (age 74.1 ± 7.5 years, 33 female) and 52 age-/gender-matched healthy controls (72.4 ± 6.4 years, 37 female). The Geriatric Depression Scale (GDS) and Rey Auditory Verbal Learning Test (RAVLT) were used to assess the severity of depressive symptoms and episodic memory function respectively. Amyloid deposition was quantified using the standardized uptake value ratio. Whole-brain voxel-wise comparisons of amyloid deposition and gray matter volume (GMV) between LLD and controls were performed. Multivariate analysis of covariance was conducted to investigate the association of regional differences in amyloid deposition and GMV with clinical factors, including GDS and RAVLT. As a result, there were no significant group differences in amyloid deposition. In contrast, LLD showed significant lower GMV in the left temporal and parietal region. GMV reduction in the left temporal region was associated with episodic memory dysfunction, but not with depression severity. Regional GMV reduction was not associated with amyloid deposition. LLD is associated with lower GMV in regions that overlap with AD-pathophysiology, and which are associated with episodic memory function. The lack of corresponding associations with amyloid suggests that lower GMV driven by non-amyloid pathology may play a central role in the neurobiology of LLD presenting as a psychiatric disorder. Trial registration: European Union Drug Regulating Authorities Clinical Trials identifier: EudraCT 2009-018064-95.Akihiro TakamiyaThomas Vande CasteeleMichel KooleFrançois-Laurent De WinterFilip BouckaertJan Van den StockStefan SunaertPatrick DupontRik VandenbergheKoen Van LaereMathieu VandenbulckeLouise EmsellNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Akihiro Takamiya Thomas Vande Casteele Michel Koole François-Laurent De Winter Filip Bouckaert Jan Van den Stock Stefan Sunaert Patrick Dupont Rik Vandenberghe Koen Van Laere Mathieu Vandenbulcke Louise Emsell Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression |
| description |
Abstract Late-life depression (LLD) is associated with a risk of developing Alzheimer’s disease (AD). However, the role of AD-pathophysiology in LLD, and its association with clinical symptoms and cognitive function are elusive. In this study, one hundred subjects underwent amyloid positron emission tomography (PET) imaging with [18F]-flutemetamol and structural MRI: 48 severely depressed elderly subjects (age 74.1 ± 7.5 years, 33 female) and 52 age-/gender-matched healthy controls (72.4 ± 6.4 years, 37 female). The Geriatric Depression Scale (GDS) and Rey Auditory Verbal Learning Test (RAVLT) were used to assess the severity of depressive symptoms and episodic memory function respectively. Amyloid deposition was quantified using the standardized uptake value ratio. Whole-brain voxel-wise comparisons of amyloid deposition and gray matter volume (GMV) between LLD and controls were performed. Multivariate analysis of covariance was conducted to investigate the association of regional differences in amyloid deposition and GMV with clinical factors, including GDS and RAVLT. As a result, there were no significant group differences in amyloid deposition. In contrast, LLD showed significant lower GMV in the left temporal and parietal region. GMV reduction in the left temporal region was associated with episodic memory dysfunction, but not with depression severity. Regional GMV reduction was not associated with amyloid deposition. LLD is associated with lower GMV in regions that overlap with AD-pathophysiology, and which are associated with episodic memory function. The lack of corresponding associations with amyloid suggests that lower GMV driven by non-amyloid pathology may play a central role in the neurobiology of LLD presenting as a psychiatric disorder. Trial registration: European Union Drug Regulating Authorities Clinical Trials identifier: EudraCT 2009-018064-95. |
| format |
article |
| author |
Akihiro Takamiya Thomas Vande Casteele Michel Koole François-Laurent De Winter Filip Bouckaert Jan Van den Stock Stefan Sunaert Patrick Dupont Rik Vandenberghe Koen Van Laere Mathieu Vandenbulcke Louise Emsell |
| author_facet |
Akihiro Takamiya Thomas Vande Casteele Michel Koole François-Laurent De Winter Filip Bouckaert Jan Van den Stock Stefan Sunaert Patrick Dupont Rik Vandenberghe Koen Van Laere Mathieu Vandenbulcke Louise Emsell |
| author_sort |
Akihiro Takamiya |
| title |
Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression |
| title_short |
Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression |
| title_full |
Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression |
| title_fullStr |
Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression |
| title_full_unstemmed |
Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression |
| title_sort |
lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/6cf5814ddb3f4fdf95d048dcf2f41a10 |
| work_keys_str_mv |
AT akihirotakamiya lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression AT thomasvandecasteele lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression AT michelkoole lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression AT francoislaurentdewinter lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression AT filipbouckaert lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression AT janvandenstock lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression AT stefansunaert lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression AT patrickdupont lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression AT rikvandenberghe lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression AT koenvanlaere lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression AT mathieuvandenbulcke lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression AT louiseemsell lowerregionalgraymattervolumeintheabsenceofhighercorticalamyloidburdeninlatelifedepression |
| _version_ |
1718381616545398784 |