The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite

Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing features with artemisinin resistance.

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Autores principales:	Min Zhang, Chengqi Wang, Jenna Oberstaller, Phaedra Thomas, Thomas D. Otto, Debora Casandra, Sandhya Boyapalle, Swamy R. Adapa, Shulin Xu, Katrina Button-Simons, Matthew Mayho, Julian C. Rayner, Michael T. Ferdig, Rays H. Y. Jiang, John H. Adams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6cf614cb2d744e3081e92819ff983c47
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spelling	oai:doaj.org-article:6cf614cb2d744e3081e92819ff983c472021-12-02T16:30:11ZThe apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite10.1038/s41467-021-24814-12041-1723https://doaj.org/article/6cf614cb2d744e3081e92819ff983c472021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24814-1https://doaj.org/toc/2041-1723Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing features with artemisinin resistance.Min ZhangChengqi WangJenna OberstallerPhaedra ThomasThomas D. OttoDebora CasandraSandhya BoyapalleSwamy R. AdapaShulin XuKatrina Button-SimonsMatthew MayhoJulian C. RaynerMichael T. FerdigRays H. Y. JiangJohn H. AdamsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Min Zhang Chengqi Wang Jenna Oberstaller Phaedra Thomas Thomas D. Otto Debora Casandra Sandhya Boyapalle Swamy R. Adapa Shulin Xu Katrina Button-Simons Matthew Mayho Julian C. Rayner Michael T. Ferdig Rays H. Y. Jiang John H. Adams The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
description	Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing features with artemisinin resistance.
format	article
author	Min Zhang Chengqi Wang Jenna Oberstaller Phaedra Thomas Thomas D. Otto Debora Casandra Sandhya Boyapalle Swamy R. Adapa Shulin Xu Katrina Button-Simons Matthew Mayho Julian C. Rayner Michael T. Ferdig Rays H. Y. Jiang John H. Adams
author_facet	Min Zhang Chengqi Wang Jenna Oberstaller Phaedra Thomas Thomas D. Otto Debora Casandra Sandhya Boyapalle Swamy R. Adapa Shulin Xu Katrina Button-Simons Matthew Mayho Julian C. Rayner Michael T. Ferdig Rays H. Y. Jiang John H. Adams
author_sort	Min Zhang
title	The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
title_short	The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
title_full	The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
title_fullStr	The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
title_full_unstemmed	The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
title_sort	apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6cf614cb2d744e3081e92819ff983c47
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The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite

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