The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite

The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite

Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing features with artemisinin resistance.

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Detalles Bibliográficos
Autores principales: Min Zhang, Chengqi Wang, Jenna Oberstaller, Phaedra Thomas, Thomas D. Otto, Debora Casandra, Sandhya Boyapalle, Swamy R. Adapa, Shulin Xu, Katrina Button-Simons, Matthew Mayho, Julian C. Rayner, Michael T. Ferdig, Rays H. Y. Jiang, John H. Adams
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/6cf614cb2d744e3081e92819ff983c47
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