Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins

Abstract Mamba venoms contain a multiplicity of three-finger fold aminergic toxins known to interact with various α-adrenergic, muscarinic and dopaminergic receptors with different pharmacological profiles. In order to generate novel functions on this structural scaffold and to avoid the daunting ta...

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Autores principales: Guillaume Blanchet, Doria Alili, Adèle Protte, Gregory Upert, Nicolas Gilles, Livia Tepshi, Enrico A. Stura, Gilles Mourier, Denis Servent
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6cf6bae70a12426a85f6c165e6b9fabf
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