Promoters are differentially sensitive to N-terminal mutant huntingtin-mediated transcriptional repression.

Huntington's disease (HD) is a neurodegenerative disorder caused by the inheritance of one mutant copy of the huntingtin gene. Mutant huntingtin protein (mHtt) contains an expanded polyglutamine repeat region near the N-terminus. Cleavage of mHtt releases an N-terminal fragment (N-mHtt) which a...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Matthew Hogel, Robert B Laprairie, Eileen M Denovan-Wright
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
R
Q
Acceso en línea:https://doaj.org/article/6cf98b69a20d48f2b48389cff0841946
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!