How Did Zika Virus Emerge in the Pacific Islands and Latin America?
ABSTRACT The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which includes microcephaly) and Guillain-Barré syndrome (GBS) have stimulated wide-ranging research. High densities of susceptible Aedes sp...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
American Society for Microbiology
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/6cfcf08fbc5c4233aa0a419300707a6a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:6cfcf08fbc5c4233aa0a419300707a6a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:6cfcf08fbc5c4233aa0a419300707a6a2021-11-15T15:50:16ZHow Did Zika Virus Emerge in the Pacific Islands and Latin America?10.1128/mBio.01239-162150-7511https://doaj.org/article/6cfcf08fbc5c4233aa0a419300707a6a2016-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01239-16https://doaj.org/toc/2150-7511ABSTRACT The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which includes microcephaly) and Guillain-Barré syndrome (GBS) have stimulated wide-ranging research. High densities of susceptible Aedes spp., immunologically naive human populations, global population growth with increased urbanization, and escalation of global transportation of humans and commercial goods carrying vectors and ZIKV undoubtedly enhanced the emergence of ZIKV. However, flavivirus mutations accumulate with time, increasing the likelihood that genetic viral differences are determinants of change in viral phenotype. Based on comparative ZIKV complete genome phylogenetic analyses and temporal estimates, we identify amino acid substitutions that may be associated with increased viral epidemicity, CZVS, and GBS. Reverse genetics, vector competence, and seroepidemiological studies will test our hypothesis that these amino acid substitutions are determinants of epidemic and neurotropic ZIKV emergence.John H.-O. PetterssonVegard EldholmStephen J. SeligmanÅke LundkvistAndrew K. FalconarMichael W. GauntDidier MussoAntoine NougairèdeRemi CharrelErnest A. GouldXavier de LamballerieAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 5 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Microbiology QR1-502 |
| spellingShingle |
Microbiology QR1-502 John H.-O. Pettersson Vegard Eldholm Stephen J. Seligman Åke Lundkvist Andrew K. Falconar Michael W. Gaunt Didier Musso Antoine Nougairède Remi Charrel Ernest A. Gould Xavier de Lamballerie How Did Zika Virus Emerge in the Pacific Islands and Latin America? |
| description |
ABSTRACT The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which includes microcephaly) and Guillain-Barré syndrome (GBS) have stimulated wide-ranging research. High densities of susceptible Aedes spp., immunologically naive human populations, global population growth with increased urbanization, and escalation of global transportation of humans and commercial goods carrying vectors and ZIKV undoubtedly enhanced the emergence of ZIKV. However, flavivirus mutations accumulate with time, increasing the likelihood that genetic viral differences are determinants of change in viral phenotype. Based on comparative ZIKV complete genome phylogenetic analyses and temporal estimates, we identify amino acid substitutions that may be associated with increased viral epidemicity, CZVS, and GBS. Reverse genetics, vector competence, and seroepidemiological studies will test our hypothesis that these amino acid substitutions are determinants of epidemic and neurotropic ZIKV emergence. |
| format |
article |
| author |
John H.-O. Pettersson Vegard Eldholm Stephen J. Seligman Åke Lundkvist Andrew K. Falconar Michael W. Gaunt Didier Musso Antoine Nougairède Remi Charrel Ernest A. Gould Xavier de Lamballerie |
| author_facet |
John H.-O. Pettersson Vegard Eldholm Stephen J. Seligman Åke Lundkvist Andrew K. Falconar Michael W. Gaunt Didier Musso Antoine Nougairède Remi Charrel Ernest A. Gould Xavier de Lamballerie |
| author_sort |
John H.-O. Pettersson |
| title |
How Did Zika Virus Emerge in the Pacific Islands and Latin America? |
| title_short |
How Did Zika Virus Emerge in the Pacific Islands and Latin America? |
| title_full |
How Did Zika Virus Emerge in the Pacific Islands and Latin America? |
| title_fullStr |
How Did Zika Virus Emerge in the Pacific Islands and Latin America? |
| title_full_unstemmed |
How Did Zika Virus Emerge in the Pacific Islands and Latin America? |
| title_sort |
how did zika virus emerge in the pacific islands and latin america? |
| publisher |
American Society for Microbiology |
| publishDate |
2016 |
| url |
https://doaj.org/article/6cfcf08fbc5c4233aa0a419300707a6a |
| work_keys_str_mv |
AT johnhopettersson howdidzikavirusemergeinthepacificislandsandlatinamerica AT vegardeldholm howdidzikavirusemergeinthepacificislandsandlatinamerica AT stephenjseligman howdidzikavirusemergeinthepacificislandsandlatinamerica AT akelundkvist howdidzikavirusemergeinthepacificislandsandlatinamerica AT andrewkfalconar howdidzikavirusemergeinthepacificislandsandlatinamerica AT michaelwgaunt howdidzikavirusemergeinthepacificislandsandlatinamerica AT didiermusso howdidzikavirusemergeinthepacificislandsandlatinamerica AT antoinenougairede howdidzikavirusemergeinthepacificislandsandlatinamerica AT remicharrel howdidzikavirusemergeinthepacificislandsandlatinamerica AT ernestagould howdidzikavirusemergeinthepacificislandsandlatinamerica AT xavierdelamballerie howdidzikavirusemergeinthepacificislandsandlatinamerica |
| _version_ |
1718427463206305792 |