Features of cytokine profile in patients with sarcoidosis

Sarcoidosis is an inflammatory disease of unknown etiology with damage to the lungs and other organs characterized by development of necrosis-free epithelioid cell granulomas. Granulomatous inflammation characterized by the activation of different immune systems cells, in particular T lymphocytes, a...

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Autores principales:	N. M. Lazareva, O. P. Baranova, I. V. Kudryavtsev, N. A. Arsentieva, N. E. Liubimova, T. P. Ses’, M. M. Ilkovich, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	sarcoidosis cytokines chemokines growth factors peripheral blood plasma Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6cfcf9a2508c4de08ea9ee9ee978d45d
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spelling	oai:doaj.org-article:6cfcf9a2508c4de08ea9ee9ee978d45d2021-11-18T08:03:50ZFeatures of cytokine profile in patients with sarcoidosis1563-06252313-741X10.15789/1563-0625-FOC-2064https://doaj.org/article/6cfcf9a2508c4de08ea9ee9ee978d45d2020-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2064https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XSarcoidosis is an inflammatory disease of unknown etiology with damage to the lungs and other organs characterized by development of necrosis-free epithelioid cell granulomas. Granulomatous inflammation characterized by the activation of different immune systems cells, in particular T lymphocytes, and the cytokines production. Our study was aimed at investigating the characteristics of the cytokine profile of blood plasma in patients with sarcoidosis. We studied peripheral blood plasma samples of patients with sarcoidosis (n = 52). The control blood samples were taken from healthy volunteers (n = 22). The level of 46 cytokines (pg/ml) was determined, as follows: IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL- 6, IL-7, IL-9, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17A, IFNα2, IFNγ, TNFα, TNFβ, IL- 1ra, IL-10, EGF, FGF-2, Flt3 Ligand, G-CSF, GM-CSF, PDGF-AA, PDGF-AB / BB, TGFα, VEGF-A, sCD40L, CCL2, CCL3, CCL4, CCL5, CCL7, CCL11, CCL17, CCL20, CCL22, CXCL1, CXCL8, CXCL9, CXCL10, CXCL11, CXCL13, CX3CL1. Significantly higher levels of interleukins and some proinflammatory cytokines were found in the patients with sarcoidosis, i.e., IL-3, 0.70 vs 0.20, p = 0.003; IL-4, 14.37 vs 3.15, p = 0.009; IL-5, 1.06 vs 0.89, p < 0.001; IL-12 (p70), 1.27 vs 0.56, p = 0.028; IL-17A, 1.48 vs 0.43, p < 0.001; IFNα2, 41.79 vs 25.04, p = 0.003; IFNγ, 4.13 vs 1.14, p < 0.001; TNFα, 21.67 vs 6.70, p < 0.001; anti-inflammatory cytokine IL-10, 1.03 vs 0.45, p = 0.019; growth factors: FGF-2, 40.08 vs 30.58, p = 0.008, G-CSF, 24.18 vs 8.21, p = 0.006, and VEGF-A, 42.52 vs 26.76, p = 0.048; chemokines: CCL3, 3.86 vs 1.33, p < 0,001; CCL17, 78.24 vs 26.24, p < 0.001; CCL20, 7.19 vs 5.64, p = 0.021; CCL22, 660.60 vs 405.00, p < 0,001; CXCL9, 4013 vs 1142, p < 0,001; CXCL10, 565.90 vs 196.60, p < 0.001; CXCL11, 230.20 vs 121.10, p = 0.018; CX3CL1, 56.99 vs 5.16, p < 0.001. Peripheral blood chemokine CCL11 levels were significantly lower in patients compared to the group of healthy volunteers: 77.58 vs 124.70, p = 0.022. The features of the cytokine profile in patients with sarcoidosis may indicate their important role in the processes of formation and outcomes of granulomas. These issues require an additional detailed study, comparison with phenotypes, differential course and outcomes of the disease.N. M. LazarevaO. P. BaranovaI. V. KudryavtsevN. A. ArsentievaN. E. LiubimovaT. P. Ses’M. M. IlkovichAreg A. TotolianSPb RAACIarticlesarcoidosiscytokineschemokinesgrowth factorsperipheral blood plasmaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 5, Pp 993-1002 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	sarcoidosis cytokines chemokines growth factors peripheral blood plasma Immunologic diseases. Allergy RC581-607
spellingShingle	sarcoidosis cytokines chemokines growth factors peripheral blood plasma Immunologic diseases. Allergy RC581-607 N. M. Lazareva O. P. Baranova I. V. Kudryavtsev N. A. Arsentieva N. E. Liubimova T. P. Ses’ M. M. Ilkovich Areg A. Totolian Features of cytokine profile in patients with sarcoidosis
description	Sarcoidosis is an inflammatory disease of unknown etiology with damage to the lungs and other organs characterized by development of necrosis-free epithelioid cell granulomas. Granulomatous inflammation characterized by the activation of different immune systems cells, in particular T lymphocytes, and the cytokines production. Our study was aimed at investigating the characteristics of the cytokine profile of blood plasma in patients with sarcoidosis. We studied peripheral blood plasma samples of patients with sarcoidosis (n = 52). The control blood samples were taken from healthy volunteers (n = 22). The level of 46 cytokines (pg/ml) was determined, as follows: IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL- 6, IL-7, IL-9, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17A, IFNα2, IFNγ, TNFα, TNFβ, IL- 1ra, IL-10, EGF, FGF-2, Flt3 Ligand, G-CSF, GM-CSF, PDGF-AA, PDGF-AB / BB, TGFα, VEGF-A, sCD40L, CCL2, CCL3, CCL4, CCL5, CCL7, CCL11, CCL17, CCL20, CCL22, CXCL1, CXCL8, CXCL9, CXCL10, CXCL11, CXCL13, CX3CL1. Significantly higher levels of interleukins and some proinflammatory cytokines were found in the patients with sarcoidosis, i.e., IL-3, 0.70 vs 0.20, p = 0.003; IL-4, 14.37 vs 3.15, p = 0.009; IL-5, 1.06 vs 0.89, p < 0.001; IL-12 (p70), 1.27 vs 0.56, p = 0.028; IL-17A, 1.48 vs 0.43, p < 0.001; IFNα2, 41.79 vs 25.04, p = 0.003; IFNγ, 4.13 vs 1.14, p < 0.001; TNFα, 21.67 vs 6.70, p < 0.001; anti-inflammatory cytokine IL-10, 1.03 vs 0.45, p = 0.019; growth factors: FGF-2, 40.08 vs 30.58, p = 0.008, G-CSF, 24.18 vs 8.21, p = 0.006, and VEGF-A, 42.52 vs 26.76, p = 0.048; chemokines: CCL3, 3.86 vs 1.33, p < 0,001; CCL17, 78.24 vs 26.24, p < 0.001; CCL20, 7.19 vs 5.64, p = 0.021; CCL22, 660.60 vs 405.00, p < 0,001; CXCL9, 4013 vs 1142, p < 0,001; CXCL10, 565.90 vs 196.60, p < 0.001; CXCL11, 230.20 vs 121.10, p = 0.018; CX3CL1, 56.99 vs 5.16, p < 0.001. Peripheral blood chemokine CCL11 levels were significantly lower in patients compared to the group of healthy volunteers: 77.58 vs 124.70, p = 0.022. The features of the cytokine profile in patients with sarcoidosis may indicate their important role in the processes of formation and outcomes of granulomas. These issues require an additional detailed study, comparison with phenotypes, differential course and outcomes of the disease.
format	article
author	N. M. Lazareva O. P. Baranova I. V. Kudryavtsev N. A. Arsentieva N. E. Liubimova T. P. Ses’ M. M. Ilkovich Areg A. Totolian
author_facet	N. M. Lazareva O. P. Baranova I. V. Kudryavtsev N. A. Arsentieva N. E. Liubimova T. P. Ses’ M. M. Ilkovich Areg A. Totolian
author_sort	N. M. Lazareva
title	Features of cytokine profile in patients with sarcoidosis
title_short	Features of cytokine profile in patients with sarcoidosis
title_full	Features of cytokine profile in patients with sarcoidosis
title_fullStr	Features of cytokine profile in patients with sarcoidosis
title_full_unstemmed	Features of cytokine profile in patients with sarcoidosis
title_sort	features of cytokine profile in patients with sarcoidosis
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/6cfcf9a2508c4de08ea9ee9ee978d45d
work_keys_str_mv	AT nmlazareva featuresofcytokineprofileinpatientswithsarcoidosis AT opbaranova featuresofcytokineprofileinpatientswithsarcoidosis AT ivkudryavtsev featuresofcytokineprofileinpatientswithsarcoidosis AT naarsentieva featuresofcytokineprofileinpatientswithsarcoidosis AT neliubimova featuresofcytokineprofileinpatientswithsarcoidosis AT tpses featuresofcytokineprofileinpatientswithsarcoidosis AT mmilkovich featuresofcytokineprofileinpatientswithsarcoidosis AT aregatotolian featuresofcytokineprofileinpatientswithsarcoidosis
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Features of cytokine profile in patients with sarcoidosis

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