Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy

Hypoxia-based agents need permeable and hypoxic intratumour environment to be effective. Here, the authors show that perfluorocarbon nanoparticles promote increased permeability and sustained hypoxia to improve accumulation of hypoxia-based agents, and inhibit intratumour oxygen reperfusion.

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Autores principales:	Wenguang Wang, Yuhao Cheng, Peng Yu, Haoran Wang, Yue Zhang, Haiheng Xu, Qingsong Ye, Ahu Yuan, Yiqiao Hu, Jinhui Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6cfdca706375493cb6365c096ce67b00
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spelling	oai:doaj.org-article:6cfdca706375493cb6365c096ce67b002021-12-02T14:39:00ZPerfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy10.1038/s41467-019-09389-22041-1723https://doaj.org/article/6cfdca706375493cb6365c096ce67b002019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09389-2https://doaj.org/toc/2041-1723Hypoxia-based agents need permeable and hypoxic intratumour environment to be effective. Here, the authors show that perfluorocarbon nanoparticles promote increased permeability and sustained hypoxia to improve accumulation of hypoxia-based agents, and inhibit intratumour oxygen reperfusion.Wenguang WangYuhao ChengPeng YuHaoran WangYue ZhangHaiheng XuQingsong YeAhu YuanYiqiao HuJinhui WuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenguang Wang Yuhao Cheng Peng Yu Haoran Wang Yue Zhang Haiheng Xu Qingsong Ye Ahu Yuan Yiqiao Hu Jinhui Wu Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
description	Hypoxia-based agents need permeable and hypoxic intratumour environment to be effective. Here, the authors show that perfluorocarbon nanoparticles promote increased permeability and sustained hypoxia to improve accumulation of hypoxia-based agents, and inhibit intratumour oxygen reperfusion.
format	article
author	Wenguang Wang Yuhao Cheng Peng Yu Haoran Wang Yue Zhang Haiheng Xu Qingsong Ye Ahu Yuan Yiqiao Hu Jinhui Wu
author_facet	Wenguang Wang Yuhao Cheng Peng Yu Haoran Wang Yue Zhang Haiheng Xu Qingsong Ye Ahu Yuan Yiqiao Hu Jinhui Wu
author_sort	Wenguang Wang
title	Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
title_short	Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
title_full	Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
title_fullStr	Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
title_full_unstemmed	Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
title_sort	perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6cfdca706375493cb6365c096ce67b00
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Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy

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