Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma
Plasmablastic lymphoma (PBL) is an aggressive lymphoma subtype characterized by poor prognosis but the molecular knowledge of the disease is limited. Here, the authors perform whole exome sequencing and copy number determination of primary samples highlighting IRF4 and JAK-STAT pathways as therapeut...
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Nature Portfolio
2021
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oai:doaj.org-article:6d054d5ed82e4409b9428afb7baa476b2021-12-02T15:26:52ZMolecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma10.1038/s41467-021-25405-w2041-1723https://doaj.org/article/6d054d5ed82e4409b9428afb7baa476b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25405-whttps://doaj.org/toc/2041-1723Plasmablastic lymphoma (PBL) is an aggressive lymphoma subtype characterized by poor prognosis but the molecular knowledge of the disease is limited. Here, the authors perform whole exome sequencing and copy number determination of primary samples highlighting IRF4 and JAK-STAT pathways as therapeutic targets for PBL.Fabian FrontzekAnnette M. StaigerMyroslav ZapukhlyakWendan XuIrina BonzheimVanessa BorgmannPhilip SanderMaria Joao BaptistaJan-Niklas HemingPhilipp BerningRamona WullenkordTabea ErdmannMathias LutzPia VerattiSophia EhrenfeldKirsty WienandHeike HornJohn R. GoodladMatthew R. WilsonIoannis AnagnostopoulosMario LampingEva Gonzalez-BarcaFina ClimentAntonio SalarJosep CastellviPau AbrisquetaJavier MenarguezTeresa AldamizJulia RichterWolfram KlapperAlexandar TzankovStefan DirnhoferAndreas RosenwaldJosé Luis MateGustavo TapiaPeter LenzCornelius MiethingWolfgang HartmannBjörn ChapuyFalko FendGerman OttJosé-Tomas NavarroMichael GrauGeorg LenzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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| collection |
DOAJ |
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EN |
| topic |
Science Q |
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Science Q Fabian Frontzek Annette M. Staiger Myroslav Zapukhlyak Wendan Xu Irina Bonzheim Vanessa Borgmann Philip Sander Maria Joao Baptista Jan-Niklas Heming Philipp Berning Ramona Wullenkord Tabea Erdmann Mathias Lutz Pia Veratti Sophia Ehrenfeld Kirsty Wienand Heike Horn John R. Goodlad Matthew R. Wilson Ioannis Anagnostopoulos Mario Lamping Eva Gonzalez-Barca Fina Climent Antonio Salar Josep Castellvi Pau Abrisqueta Javier Menarguez Teresa Aldamiz Julia Richter Wolfram Klapper Alexandar Tzankov Stefan Dirnhofer Andreas Rosenwald José Luis Mate Gustavo Tapia Peter Lenz Cornelius Miething Wolfgang Hartmann Björn Chapuy Falko Fend German Ott José-Tomas Navarro Michael Grau Georg Lenz Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma |
| description |
Plasmablastic lymphoma (PBL) is an aggressive lymphoma subtype characterized by poor prognosis but the molecular knowledge of the disease is limited. Here, the authors perform whole exome sequencing and copy number determination of primary samples highlighting IRF4 and JAK-STAT pathways as therapeutic targets for PBL. |
| format |
article |
| author |
Fabian Frontzek Annette M. Staiger Myroslav Zapukhlyak Wendan Xu Irina Bonzheim Vanessa Borgmann Philip Sander Maria Joao Baptista Jan-Niklas Heming Philipp Berning Ramona Wullenkord Tabea Erdmann Mathias Lutz Pia Veratti Sophia Ehrenfeld Kirsty Wienand Heike Horn John R. Goodlad Matthew R. Wilson Ioannis Anagnostopoulos Mario Lamping Eva Gonzalez-Barca Fina Climent Antonio Salar Josep Castellvi Pau Abrisqueta Javier Menarguez Teresa Aldamiz Julia Richter Wolfram Klapper Alexandar Tzankov Stefan Dirnhofer Andreas Rosenwald José Luis Mate Gustavo Tapia Peter Lenz Cornelius Miething Wolfgang Hartmann Björn Chapuy Falko Fend German Ott José-Tomas Navarro Michael Grau Georg Lenz |
| author_facet |
Fabian Frontzek Annette M. Staiger Myroslav Zapukhlyak Wendan Xu Irina Bonzheim Vanessa Borgmann Philip Sander Maria Joao Baptista Jan-Niklas Heming Philipp Berning Ramona Wullenkord Tabea Erdmann Mathias Lutz Pia Veratti Sophia Ehrenfeld Kirsty Wienand Heike Horn John R. Goodlad Matthew R. Wilson Ioannis Anagnostopoulos Mario Lamping Eva Gonzalez-Barca Fina Climent Antonio Salar Josep Castellvi Pau Abrisqueta Javier Menarguez Teresa Aldamiz Julia Richter Wolfram Klapper Alexandar Tzankov Stefan Dirnhofer Andreas Rosenwald José Luis Mate Gustavo Tapia Peter Lenz Cornelius Miething Wolfgang Hartmann Björn Chapuy Falko Fend German Ott José-Tomas Navarro Michael Grau Georg Lenz |
| author_sort |
Fabian Frontzek |
| title |
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma |
| title_short |
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma |
| title_full |
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma |
| title_fullStr |
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma |
| title_full_unstemmed |
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma |
| title_sort |
molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/6d054d5ed82e4409b9428afb7baa476b |
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