Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?

Abstract Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is known to suppress the antioxidant system and is likely to aggravate severity of COVID-19, which results in a pro-oxidant response. This possible association has not been explored adequately in human studies. In this research, we report...

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Autores principales:	Nitya Kumar, AbdulKarim AbdulRahman, Abdulla Ismaeel AlAwadhi, Manaf AlQahtani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d06403b22444337b64d678cb4f75700
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spelling	oai:doaj.org-article:6d06403b22444337b64d678cb4f757002021-12-02T17:18:22ZIs glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?10.1038/s41598-021-98712-32045-2322https://doaj.org/article/6d06403b22444337b64d678cb4f757002021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98712-3https://doaj.org/toc/2045-2322Abstract Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is known to suppress the antioxidant system and is likely to aggravate severity of COVID-19, which results in a pro-oxidant response. This possible association has not been explored adequately in human studies. In this research, we report that the occurrence of non-invasive ventilation, intubation or death—all of which are indicative of severe COVID-19, are not significantly different in hospitalized COVID-19 patients with and without G6PDd (4.6 vs. 6.4%, p = 0.33). The likelihood of developing any of these severe outcomes were slightly lower in patients with G6PDd after accounting for age, nationality, presence of comorbidities and drug interventions (Odds ratio 0.40, 95% confidence intervals 0.142, 1.148). Further investigation that extends to both, hospitalized and non-hospitalized COVID-19 patients, is warranted to study this potential association.Nitya KumarAbdulKarim AbdulRahmanAbdulla Ismaeel AlAwadhiManaf AlQahtaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nitya Kumar AbdulKarim AbdulRahman Abdulla Ismaeel AlAwadhi Manaf AlQahtani Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?
description	Abstract Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is known to suppress the antioxidant system and is likely to aggravate severity of COVID-19, which results in a pro-oxidant response. This possible association has not been explored adequately in human studies. In this research, we report that the occurrence of non-invasive ventilation, intubation or death—all of which are indicative of severe COVID-19, are not significantly different in hospitalized COVID-19 patients with and without G6PDd (4.6 vs. 6.4%, p = 0.33). The likelihood of developing any of these severe outcomes were slightly lower in patients with G6PDd after accounting for age, nationality, presence of comorbidities and drug interventions (Odds ratio 0.40, 95% confidence intervals 0.142, 1.148). Further investigation that extends to both, hospitalized and non-hospitalized COVID-19 patients, is warranted to study this potential association.
format	article
author	Nitya Kumar AbdulKarim AbdulRahman Abdulla Ismaeel AlAwadhi Manaf AlQahtani
author_facet	Nitya Kumar AbdulKarim AbdulRahman Abdulla Ismaeel AlAwadhi Manaf AlQahtani
author_sort	Nitya Kumar
title	Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?
title_short	Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?
title_full	Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?
title_fullStr	Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?
title_full_unstemmed	Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?
title_sort	is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized covid-19 patients?
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6d06403b22444337b64d678cb4f75700
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Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?

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