ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS

Bacteria Klebsiella pneumoniae is one of the most common and dangerous pathogens of human infectious diseases. The research of K. pneumoniae resistance to ß-lactam antibiotics (cephalosporins), which are widely used in anti-infective therapy, is very relevant. The aims of the work is to study K. pne...

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Autores principales:	E. V. Anganova, L. A. Raspopina, A. V. Vetokhina, A. V. Dukhanina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	klebsiella pneumoniae antibiotic resistance cephalosporins Science Q
Acceso en línea:	https://doaj.org/article/6d080d3ced4d4626b5f31f5d7a4859c7
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spelling	oai:doaj.org-article:6d080d3ced4d4626b5f31f5d7a4859c72021-11-23T06:14:38ZANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS2541-94202587-959610.12737/article_59fad513099c94.94562871https://doaj.org/article/6d080d3ced4d4626b5f31f5d7a4859c72017-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/410https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Bacteria Klebsiella pneumoniae is one of the most common and dangerous pathogens of human infectious diseases. The research of K. pneumoniae resistance to ß-lactam antibiotics (cephalosporins), which are widely used in anti-infective therapy, is very relevant. The aims of the work is to study K. pneumoniae resistance to cephalosporins. Fifty strains of K. pneumoniae isolated from patients (sputum, lavage liquid, blood) of Irkutsk Regional Clinical Hospital and sectional material in 2015 were examined. Resistance to four antibiotics (cefotaxime, ceftriaxone, ceftazidime, cefepime) was determined by disco-diffusion method. 56.0-62.0 % of K. pneumoniae strains were resistant to drugs of 111 generation cephalosporins; 58.0 % - to drug of 1Vgeneration (cefepime). Klebsiella strains showed the highest resistance to ceftazidime (resistance - 62.0 %; intermediate - 20.0 %). The spectrum of resistance to all four antibiotics was revealed in 52.0 % of strains, cross-resistance - in 64.0 %. The resistance of K. pneumoniae from the sectional material was higher than resistance of Klebsiella isolated from the organs and tissues of the patients. Klebsiella isolated from the lavage fluid more often (p < 0.05) showed resistance to cephalosporins compared to strains isolated from sputum. The research brought us to the conclusion that Klebsiella pneumoniae strains were characterized by a significant level of resistance to ß-lactam antibiotics (cephalosporins).E. V. AnganovaL. A. RaspopinaA. V. VetokhinaA. V. DukhaninaScientific Сentre for Family Health and Human Reproduction Problemsarticleklebsiella pneumoniaeklebsiella pneumoniaeantibiotic resistancecephalosporinsScienceQRUActa Biomedica Scientifica, Vol 2, Iss 4, Pp 43-47 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	klebsiella pneumoniae klebsiella pneumoniae antibiotic resistance cephalosporins Science Q
spellingShingle	klebsiella pneumoniae klebsiella pneumoniae antibiotic resistance cephalosporins Science Q E. V. Anganova L. A. Raspopina A. V. Vetokhina A. V. Dukhanina ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS
description	Bacteria Klebsiella pneumoniae is one of the most common and dangerous pathogens of human infectious diseases. The research of K. pneumoniae resistance to ß-lactam antibiotics (cephalosporins), which are widely used in anti-infective therapy, is very relevant. The aims of the work is to study K. pneumoniae resistance to cephalosporins. Fifty strains of K. pneumoniae isolated from patients (sputum, lavage liquid, blood) of Irkutsk Regional Clinical Hospital and sectional material in 2015 were examined. Resistance to four antibiotics (cefotaxime, ceftriaxone, ceftazidime, cefepime) was determined by disco-diffusion method. 56.0-62.0 % of K. pneumoniae strains were resistant to drugs of 111 generation cephalosporins; 58.0 % - to drug of 1Vgeneration (cefepime). Klebsiella strains showed the highest resistance to ceftazidime (resistance - 62.0 %; intermediate - 20.0 %). The spectrum of resistance to all four antibiotics was revealed in 52.0 % of strains, cross-resistance - in 64.0 %. The resistance of K. pneumoniae from the sectional material was higher than resistance of Klebsiella isolated from the organs and tissues of the patients. Klebsiella isolated from the lavage fluid more often (p < 0.05) showed resistance to cephalosporins compared to strains isolated from sputum. The research brought us to the conclusion that Klebsiella pneumoniae strains were characterized by a significant level of resistance to ß-lactam antibiotics (cephalosporins).
format	article
author	E. V. Anganova L. A. Raspopina A. V. Vetokhina A. V. Dukhanina
author_facet	E. V. Anganova L. A. Raspopina A. V. Vetokhina A. V. Dukhanina
author_sort	E. V. Anganova
title	ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS
title_short	ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS
title_full	ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS
title_fullStr	ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS
title_full_unstemmed	ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS
title_sort	antibiotic resistance of klebsiella pneumoniae to cephalosporins
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/6d080d3ced4d4626b5f31f5d7a4859c7
work_keys_str_mv	AT evanganova antibioticresistanceofklebsiellapneumoniaetocephalosporins AT laraspopina antibioticresistanceofklebsiellapneumoniaetocephalosporins AT avvetokhina antibioticresistanceofklebsiellapneumoniaetocephalosporins AT avdukhanina antibioticresistanceofklebsiellapneumoniaetocephalosporins
_version_	1718417012115374080

ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS

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