Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease

Introduction: Adipokines, expressed by adipose tissue (AT), have been associated with metabolic disturbances and coronary artery disease (CAD). The impact of exercise training on the AT in patients suffering from both diabetes and CAD is unknown. To gain knowledge on changes in ATs’ inflammatory pro...

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Autores principales:	Hani Zaidi, Rune Byrkjeland, Ida U. Njerve, Sissel Åkra, Svein Solheim, Harald Arnesen, Ingebjørg Seljeflot, Trine B. Opstad
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	adiponectin vo2peak exercise-training coronary artery disease type 2 diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/6d083d9a420742e2999bf8964f9c7efa
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spelling	oai:doaj.org-article:6d083d9a420742e2999bf8964f9c7efa2021-11-17T14:21:59ZAdiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease2162-39452162-397X10.1080/21623945.2021.1996699https://doaj.org/article/6d083d9a420742e2999bf8964f9c7efa2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/21623945.2021.1996699https://doaj.org/toc/2162-3945https://doaj.org/toc/2162-397XIntroduction: Adipokines, expressed by adipose tissue (AT), have been associated with metabolic disturbances and coronary artery disease (CAD). The impact of exercise training on the AT in patients suffering from both diabetes and CAD is unknown. To gain knowledge on changes in ATs’ inflammatory profile in such a population, we investigated the effects of long-term exercise on selected adipokines and their associations with physical performance and glucometabolic variables. Adiponectin was selected based on its anti-atherogenic and anti-diabetic properties and visfatin and tumour necrosis factor (TNF) for their association with atherosclerosis and metabolic disorders. Not many studies have focused on the effects of long-term exercise training on adipokines in patients with concomitant T2DM and CAD. Methods: Patients with type 2 diabetes and CAD (n = 137), 41–81 years, 17.2% females, were randomized in a 1:1 manner to an exercise group, who underwent 1 year of 150 min weekly combined strength and endurance exercise, or a control group. AT from the gluteal region and blood samples were obtained at baseline and after 12 months, along with a physical performance test, assessed by the VO2 peak. Circulating protein levels were measured by ELISA. RNA was extracted from AT and expression levels were relatively quantified by PCR. Results: After 1 year, no significant difference in the change in the investigated markers between the intervention group and the control group was observed. Changes in circulating adiponectin and VO2 peak correlated in the total population (r = 0.256, p = 0.008). At baseline, circulating adiponectin and TNF correlated inversely with insulin and with C-peptide and VO2peak, respectively (p < 0.001, all). Conclusion: In this population with concomitant diabetes and CAD, ATs’ inflammatory profile remained unchanged apparently after 1 year of exercise intervention. Changes in the VO2peak were nevertheless, related to changes in circulating adiponectin levels. Trial registration: http://www.clinicaltrials.gov NCT01232608.Hani ZaidiRune ByrkjelandIda U. NjerveSissel ÅkraSvein SolheimHarald ArnesenIngebjørg SeljeflotTrine B. OpstadTaylor & Francis Grouparticleadiponectinvo2peakexercise-trainingcoronary artery diseasetype 2 diabetesDiseases of the endocrine glands. Clinical endocrinologyRC648-665CytologyQH573-671PhysiologyQP1-981ENAdipocyte, Vol 10, Iss 1, Pp 612-620 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adiponectin vo2peak exercise-training coronary artery disease type 2 diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981
spellingShingle	adiponectin vo2peak exercise-training coronary artery disease type 2 diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981 Hani Zaidi Rune Byrkjeland Ida U. Njerve Sissel Åkra Svein Solheim Harald Arnesen Ingebjørg Seljeflot Trine B. Opstad Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease
description	Introduction: Adipokines, expressed by adipose tissue (AT), have been associated with metabolic disturbances and coronary artery disease (CAD). The impact of exercise training on the AT in patients suffering from both diabetes and CAD is unknown. To gain knowledge on changes in ATs’ inflammatory profile in such a population, we investigated the effects of long-term exercise on selected adipokines and their associations with physical performance and glucometabolic variables. Adiponectin was selected based on its anti-atherogenic and anti-diabetic properties and visfatin and tumour necrosis factor (TNF) for their association with atherosclerosis and metabolic disorders. Not many studies have focused on the effects of long-term exercise training on adipokines in patients with concomitant T2DM and CAD. Methods: Patients with type 2 diabetes and CAD (n = 137), 41–81 years, 17.2% females, were randomized in a 1:1 manner to an exercise group, who underwent 1 year of 150 min weekly combined strength and endurance exercise, or a control group. AT from the gluteal region and blood samples were obtained at baseline and after 12 months, along with a physical performance test, assessed by the VO2 peak. Circulating protein levels were measured by ELISA. RNA was extracted from AT and expression levels were relatively quantified by PCR. Results: After 1 year, no significant difference in the change in the investigated markers between the intervention group and the control group was observed. Changes in circulating adiponectin and VO2 peak correlated in the total population (r = 0.256, p = 0.008). At baseline, circulating adiponectin and TNF correlated inversely with insulin and with C-peptide and VO2peak, respectively (p < 0.001, all). Conclusion: In this population with concomitant diabetes and CAD, ATs’ inflammatory profile remained unchanged apparently after 1 year of exercise intervention. Changes in the VO2peak were nevertheless, related to changes in circulating adiponectin levels. Trial registration: http://www.clinicaltrials.gov NCT01232608.
format	article
author	Hani Zaidi Rune Byrkjeland Ida U. Njerve Sissel Åkra Svein Solheim Harald Arnesen Ingebjørg Seljeflot Trine B. Opstad
author_facet	Hani Zaidi Rune Byrkjeland Ida U. Njerve Sissel Åkra Svein Solheim Harald Arnesen Ingebjørg Seljeflot Trine B. Opstad
author_sort	Hani Zaidi
title	Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease
title_short	Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease
title_full	Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease
title_fullStr	Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease
title_full_unstemmed	Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease
title_sort	adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/6d083d9a420742e2999bf8964f9c7efa
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Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease

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