The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration
HMBG1 is a protein expressed in natural killer cells and is important in immunosurveillance. In this study, the authors show that HMGB1 binds to and inhibits PKM2, resulting in a block in aerobic glycolysis and ultimately cell death.
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Nature Portfolio
2016
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oai:doaj.org-article:6d0982f20a704f85b9b090631aa6eb7d2021-12-02T17:33:07ZThe HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration10.1038/ncomms107642041-1723https://doaj.org/article/6d0982f20a704f85b9b090631aa6eb7d2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10764https://doaj.org/toc/2041-1723HMBG1 is a protein expressed in natural killer cells and is important in immunosurveillance. In this study, the authors show that HMGB1 binds to and inhibits PKM2, resulting in a block in aerobic glycolysis and ultimately cell death.Georg GdyniaSven W. SauerJürgen KopitzDominik FuchsKatarina DuglovaThorsten RuppertMatthias MillerJens PahlAdelheid CerwenkaMarkus EndersHeimo MairbäurlMarcin M. KamińskiRoland PenzelChristine ZhangJonathan C. FullerRebecca C. WadeAxel BennerJenny Chang-ClaudeHermann BrennerMichael HoffmeisterHanswalter ZentgrafPeter SchirmacherWilfried RothNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Georg Gdynia Sven W. Sauer Jürgen Kopitz Dominik Fuchs Katarina Duglova Thorsten Ruppert Matthias Miller Jens Pahl Adelheid Cerwenka Markus Enders Heimo Mairbäurl Marcin M. Kamiński Roland Penzel Christine Zhang Jonathan C. Fuller Rebecca C. Wade Axel Benner Jenny Chang-Claude Hermann Brenner Michael Hoffmeister Hanswalter Zentgraf Peter Schirmacher Wilfried Roth The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration |
| description |
HMBG1 is a protein expressed in natural killer cells and is important in immunosurveillance. In this study, the authors show that HMGB1 binds to and inhibits PKM2, resulting in a block in aerobic glycolysis and ultimately cell death. |
| format |
article |
| author |
Georg Gdynia Sven W. Sauer Jürgen Kopitz Dominik Fuchs Katarina Duglova Thorsten Ruppert Matthias Miller Jens Pahl Adelheid Cerwenka Markus Enders Heimo Mairbäurl Marcin M. Kamiński Roland Penzel Christine Zhang Jonathan C. Fuller Rebecca C. Wade Axel Benner Jenny Chang-Claude Hermann Brenner Michael Hoffmeister Hanswalter Zentgraf Peter Schirmacher Wilfried Roth |
| author_facet |
Georg Gdynia Sven W. Sauer Jürgen Kopitz Dominik Fuchs Katarina Duglova Thorsten Ruppert Matthias Miller Jens Pahl Adelheid Cerwenka Markus Enders Heimo Mairbäurl Marcin M. Kamiński Roland Penzel Christine Zhang Jonathan C. Fuller Rebecca C. Wade Axel Benner Jenny Chang-Claude Hermann Brenner Michael Hoffmeister Hanswalter Zentgraf Peter Schirmacher Wilfried Roth |
| author_sort |
Georg Gdynia |
| title |
The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration |
| title_short |
The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration |
| title_full |
The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration |
| title_fullStr |
The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration |
| title_full_unstemmed |
The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration |
| title_sort |
hmgb1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/6d0982f20a704f85b9b090631aa6eb7d |
| work_keys_str_mv |
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