Sulfated Hyaluronan coating of polyurethanebased implant materials

Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubberlike properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kemkemer Ralf, Athanasopulu Kiriaki, Caltzidou Dimitra, Sekishita Asuka, Kutuzova Larysa, Lorenz Günter, Tanaka Masaru
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	purs surface modification sulfated hyaluronic acid implant coating Medicine R
Acceso en línea:	https://doaj.org/article/6d0b012e0b8b4ce4b26e6c054d1c211d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6d0b012e0b8b4ce4b26e6c054d1c211d
record_format	dspace
spelling	oai:doaj.org-article:6d0b012e0b8b4ce4b26e6c054d1c211d2021-12-05T14:10:43ZSulfated Hyaluronan coating of polyurethanebased implant materials2364-550410.1515/cdbme-2020-3115https://doaj.org/article/6d0b012e0b8b4ce4b26e6c054d1c211d2020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3115https://doaj.org/toc/2364-5504Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubberlike properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments.Kemkemer RalfAthanasopulu KiriakiCaltzidou DimitraSekishita AsukaKutuzova LarysaLorenz GünterTanaka MasaruDe Gruyterarticlepurssurface modificationsulfated hyaluronic acidimplant coatingMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 446-449 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	purs surface modification sulfated hyaluronic acid implant coating Medicine R
spellingShingle	purs surface modification sulfated hyaluronic acid implant coating Medicine R Kemkemer Ralf Athanasopulu Kiriaki Caltzidou Dimitra Sekishita Asuka Kutuzova Larysa Lorenz Günter Tanaka Masaru Sulfated Hyaluronan coating of polyurethanebased implant materials
description	Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubberlike properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments.
format	article
author	Kemkemer Ralf Athanasopulu Kiriaki Caltzidou Dimitra Sekishita Asuka Kutuzova Larysa Lorenz Günter Tanaka Masaru
author_facet	Kemkemer Ralf Athanasopulu Kiriaki Caltzidou Dimitra Sekishita Asuka Kutuzova Larysa Lorenz Günter Tanaka Masaru
author_sort	Kemkemer Ralf
title	Sulfated Hyaluronan coating of polyurethanebased implant materials
title_short	Sulfated Hyaluronan coating of polyurethanebased implant materials
title_full	Sulfated Hyaluronan coating of polyurethanebased implant materials
title_fullStr	Sulfated Hyaluronan coating of polyurethanebased implant materials
title_full_unstemmed	Sulfated Hyaluronan coating of polyurethanebased implant materials
title_sort	sulfated hyaluronan coating of polyurethanebased implant materials
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/6d0b012e0b8b4ce4b26e6c054d1c211d
work_keys_str_mv	AT kemkemerralf sulfatedhyaluronancoatingofpolyurethanebasedimplantmaterials AT athanasopulukiriaki sulfatedhyaluronancoatingofpolyurethanebasedimplantmaterials AT caltzidoudimitra sulfatedhyaluronancoatingofpolyurethanebasedimplantmaterials AT sekishitaasuka sulfatedhyaluronancoatingofpolyurethanebasedimplantmaterials AT kutuzovalarysa sulfatedhyaluronancoatingofpolyurethanebasedimplantmaterials AT lorenzgunter sulfatedhyaluronancoatingofpolyurethanebasedimplantmaterials AT tanakamasaru sulfatedhyaluronancoatingofpolyurethanebasedimplantmaterials
_version_	1718371791234138112

Sulfated Hyaluronan coating of polyurethanebased implant materials

Ejemplares similares