Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

Here the authors examine how m6A modification is involved in innate immunity. They show that RNA methyltransferase Mettl3-mediated mRNA m6A methylation promotes dendritic cell (DC) activation and function, and in promoting DC-based T cells responses.

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Detalles Bibliográficos
Autores principales: Huamin Wang, Xiang Hu, Mingyan Huang, Juan Liu, Yan Gu, Lijia Ma, Qi Zhou, Xuetao Cao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/6d0f8a72cd97484f9c890a636b469a4d
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Descripción
Sumario:Here the authors examine how m6A modification is involved in innate immunity. They show that RNA methyltransferase Mettl3-mediated mRNA m6A methylation promotes dendritic cell (DC) activation and function, and in promoting DC-based T cells responses.