Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

Here the authors examine how m6A modification is involved in innate immunity. They show that RNA methyltransferase Mettl3-mediated mRNA m6A methylation promotes dendritic cell (DC) activation and function, and in promoting DC-based T cells responses.

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Autores principales:	Huamin Wang, Xiang Hu, Mingyan Huang, Juan Liu, Yan Gu, Lijia Ma, Qi Zhou, Xuetao Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d0f8a72cd97484f9c890a636b469a4d
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spelling	oai:doaj.org-article:6d0f8a72cd97484f9c890a636b469a4d2021-12-02T17:02:09ZMettl3-mediated mRNA m6A methylation promotes dendritic cell activation10.1038/s41467-019-09903-62041-1723https://doaj.org/article/6d0f8a72cd97484f9c890a636b469a4d2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09903-6https://doaj.org/toc/2041-1723Here the authors examine how m6A modification is involved in innate immunity. They show that RNA methyltransferase Mettl3-mediated mRNA m6A methylation promotes dendritic cell (DC) activation and function, and in promoting DC-based T cells responses.Huamin WangXiang HuMingyan HuangJuan LiuYan GuLijia MaQi ZhouXuetao CaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huamin Wang Xiang Hu Mingyan Huang Juan Liu Yan Gu Lijia Ma Qi Zhou Xuetao Cao Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
description	Here the authors examine how m6A modification is involved in innate immunity. They show that RNA methyltransferase Mettl3-mediated mRNA m6A methylation promotes dendritic cell (DC) activation and function, and in promoting DC-based T cells responses.
format	article
author	Huamin Wang Xiang Hu Mingyan Huang Juan Liu Yan Gu Lijia Ma Qi Zhou Xuetao Cao
author_facet	Huamin Wang Xiang Hu Mingyan Huang Juan Liu Yan Gu Lijia Ma Qi Zhou Xuetao Cao
author_sort	Huamin Wang
title	Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
title_short	Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
title_full	Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
title_fullStr	Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
title_full_unstemmed	Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
title_sort	mettl3-mediated mrna m6a methylation promotes dendritic cell activation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6d0f8a72cd97484f9c890a636b469a4d
work_keys_str_mv	AT huaminwang mettl3mediatedmrnam6amethylationpromotesdendriticcellactivation AT xianghu mettl3mediatedmrnam6amethylationpromotesdendriticcellactivation AT mingyanhuang mettl3mediatedmrnam6amethylationpromotesdendriticcellactivation AT juanliu mettl3mediatedmrnam6amethylationpromotesdendriticcellactivation AT yangu mettl3mediatedmrnam6amethylationpromotesdendriticcellactivation AT lijiama mettl3mediatedmrnam6amethylationpromotesdendriticcellactivation AT qizhou mettl3mediatedmrnam6amethylationpromotesdendriticcellactivation AT xuetaocao mettl3mediatedmrnam6amethylationpromotesdendriticcellactivation
_version_	1718381973116813312

Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

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