miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis

miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis

The transcription factor CHOP/GADD153 regulates apoptosis in response to the unfolded protein response. Here the authors show that CHOP/GADD153 regulates the expression of miR-216b, which targets c-Jun and sensitizes cells to ER stress-dependent apoptosis.

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Autores principales: Zhenhua Xu, Yiwen Bu, Nilesh Chitnis, Costas Koumenis, Serge Y. Fuchs, J. Alan Diehl
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6d137a4778be455fb9413524429c2495
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spelling oai:doaj.org-article:6d137a4778be455fb9413524429c24952021-12-02T16:57:05ZmiR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis10.1038/ncomms114222041-1723https://doaj.org/article/6d137a4778be455fb9413524429c24952016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11422https://doaj.org/toc/2041-1723The transcription factor CHOP/GADD153 regulates apoptosis in response to the unfolded protein response. Here the authors show that CHOP/GADD153 regulates the expression of miR-216b, which targets c-Jun and sensitizes cells to ER stress-dependent apoptosis.Zhenhua XuYiwen BuNilesh ChitnisCostas KoumenisSerge Y. FuchsJ. Alan DiehlNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhenhua Xu
Yiwen Bu
Nilesh Chitnis
Costas Koumenis
Serge Y. Fuchs
J. Alan Diehl
miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis
description The transcription factor CHOP/GADD153 regulates apoptosis in response to the unfolded protein response. Here the authors show that CHOP/GADD153 regulates the expression of miR-216b, which targets c-Jun and sensitizes cells to ER stress-dependent apoptosis.
format article
author Zhenhua Xu
Yiwen Bu
Nilesh Chitnis
Costas Koumenis
Serge Y. Fuchs
J. Alan Diehl
author_facet Zhenhua Xu
Yiwen Bu
Nilesh Chitnis
Costas Koumenis
Serge Y. Fuchs
J. Alan Diehl
author_sort Zhenhua Xu
title miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis
title_short miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis
title_full miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis
title_fullStr miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis
title_full_unstemmed miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis
title_sort mir-216b regulation of c-jun mediates gadd153/chop-dependent apoptosis
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/6d137a4778be455fb9413524429c2495
work_keys_str_mv AT zhenhuaxu mir216bregulationofcjunmediatesgadd153chopdependentapoptosis
AT yiwenbu mir216bregulationofcjunmediatesgadd153chopdependentapoptosis
AT nileshchitnis mir216bregulationofcjunmediatesgadd153chopdependentapoptosis
AT costaskoumenis mir216bregulationofcjunmediatesgadd153chopdependentapoptosis
AT sergeyfuchs mir216bregulationofcjunmediatesgadd153chopdependentapoptosis
AT jalandiehl mir216bregulationofcjunmediatesgadd153chopdependentapoptosis
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