Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2

Clinical CDK4/6 inhibitors are used and tested to treat a variety of cancer types. Here, the authors identify that these drugs work in two ways, a known catalytic role to inhibit kinase activity and a newly discovered noncatalytic role to displace CDK inhibitor p21 from CDK4 but not CDK6 complexes.

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Autores principales: Lindsey R. Pack, Leighton H. Daigh, Mingyu Chung, Tobias Meyer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6d14f142aabc4361a0362428e11c38f1
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spelling oai:doaj.org-article:6d14f142aabc4361a0362428e11c38f12021-12-02T17:52:09ZClinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK210.1038/s41467-021-23612-z2041-1723https://doaj.org/article/6d14f142aabc4361a0362428e11c38f12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23612-zhttps://doaj.org/toc/2041-1723Clinical CDK4/6 inhibitors are used and tested to treat a variety of cancer types. Here, the authors identify that these drugs work in two ways, a known catalytic role to inhibit kinase activity and a newly discovered noncatalytic role to displace CDK inhibitor p21 from CDK4 but not CDK6 complexes.Lindsey R. PackLeighton H. DaighMingyu ChungTobias MeyerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lindsey R. Pack
Leighton H. Daigh
Mingyu Chung
Tobias Meyer
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
description Clinical CDK4/6 inhibitors are used and tested to treat a variety of cancer types. Here, the authors identify that these drugs work in two ways, a known catalytic role to inhibit kinase activity and a newly discovered noncatalytic role to displace CDK inhibitor p21 from CDK4 but not CDK6 complexes.
format article
author Lindsey R. Pack
Leighton H. Daigh
Mingyu Chung
Tobias Meyer
author_facet Lindsey R. Pack
Leighton H. Daigh
Mingyu Chung
Tobias Meyer
author_sort Lindsey R. Pack
title Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
title_short Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
title_full Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
title_fullStr Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
title_full_unstemmed Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
title_sort clinical cdk4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin d-cdk4 to inhibit cdk2
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/6d14f142aabc4361a0362428e11c38f1
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AT mingyuchung clinicalcdk46inhibitorsinduceselectiveandimmediatedissociationofp21fromcyclindcdk4toinhibitcdk2
AT tobiasmeyer clinicalcdk46inhibitorsinduceselectiveandimmediatedissociationofp21fromcyclindcdk4toinhibitcdk2
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