Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
Clinical CDK4/6 inhibitors are used and tested to treat a variety of cancer types. Here, the authors identify that these drugs work in two ways, a known catalytic role to inhibit kinase activity and a newly discovered noncatalytic role to displace CDK inhibitor p21 from CDK4 but not CDK6 complexes.
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Nature Portfolio
2021
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oai:doaj.org-article:6d14f142aabc4361a0362428e11c38f12021-12-02T17:52:09ZClinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK210.1038/s41467-021-23612-z2041-1723https://doaj.org/article/6d14f142aabc4361a0362428e11c38f12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23612-zhttps://doaj.org/toc/2041-1723Clinical CDK4/6 inhibitors are used and tested to treat a variety of cancer types. Here, the authors identify that these drugs work in two ways, a known catalytic role to inhibit kinase activity and a newly discovered noncatalytic role to displace CDK inhibitor p21 from CDK4 but not CDK6 complexes.Lindsey R. PackLeighton H. DaighMingyu ChungTobias MeyerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
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Science Q Lindsey R. Pack Leighton H. Daigh Mingyu Chung Tobias Meyer Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2 |
description |
Clinical CDK4/6 inhibitors are used and tested to treat a variety of cancer types. Here, the authors identify that these drugs work in two ways, a known catalytic role to inhibit kinase activity and a newly discovered noncatalytic role to displace CDK inhibitor p21 from CDK4 but not CDK6 complexes. |
format |
article |
author |
Lindsey R. Pack Leighton H. Daigh Mingyu Chung Tobias Meyer |
author_facet |
Lindsey R. Pack Leighton H. Daigh Mingyu Chung Tobias Meyer |
author_sort |
Lindsey R. Pack |
title |
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2 |
title_short |
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2 |
title_full |
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2 |
title_fullStr |
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2 |
title_full_unstemmed |
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2 |
title_sort |
clinical cdk4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin d-cdk4 to inhibit cdk2 |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/6d14f142aabc4361a0362428e11c38f1 |
work_keys_str_mv |
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_version_ |
1718379232021708800 |