Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018.

<h4>Introduction</h4>Acute Q fever is endemic in Israel, yet the clinical and laboratory picture is poorly defined.<h4>Methods</h4>A retrospective study reviewing the medical records of acute Q fever patients, conducted in a single hospital in the Sharon district, Israel. Ser...

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Autores principales:	Talya Finn, Frida Babushkin, Keren Geller, Hanna Alexander, Svetlana Paikin, Jonathan Lellouche, Yafit Atiya-Nasagi, Regev Cohen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/6d17794663aa42ffa5b1bebeb17cecc1
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spelling	oai:doaj.org-article:6d17794663aa42ffa5b1bebeb17cecc12021-12-02T20:23:45ZEpidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018.1935-27271935-273510.1371/journal.pntd.0009573https://doaj.org/article/6d17794663aa42ffa5b1bebeb17cecc12021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009573https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Introduction</h4>Acute Q fever is endemic in Israel, yet the clinical and laboratory picture is poorly defined.<h4>Methods</h4>A retrospective study reviewing the medical records of acute Q fever patients, conducted in a single hospital in the Sharon district, Israel. Serum samples from suspected cases were preliminary tested by a qualitative enzyme immunoassay (EIA). Confirmatory testing at the reference laboratory used an indirect immunofluorescence assay (IFA). Positive cases were defined as fever with at least one other symptom and accepted laboratory criteria such as a single-phase II immunoglobulin G (IgG) antibody titer ≥1:200. Cases not fulfilling these criteria and in which acute Q fever was excluded, served as a control group.<h4>Results</h4>Between January 2012 and May 2018, 484 patients tested positive. After confirmatory testing, 65 (13.4%) were positive for acute Q fever (with requisite clinical picture), 171 (35.3%) were definitely not infected, the remaining 248 were excluded because of past/chronic/undetermined infection. The average age was 58 years and 66% were males. Most resided in urban areas with rare animal exposure. Pneumonia was seen in 57% of cases and a combination with headache/hepatitis was highly suggestive of acute Q fever diagnosis. Syncope/presyncope, fall and arthritis were more common in acute Q fever cases. Laboratory indexes were similar to the control group, except for erythrocyte sedimentation rate (ESR) which was more common and higher in the study group.<h4>Conclusion</h4>Acute Q fever in the Sharon district could be better diagnosed by using a syndromic approach in combination with improved rapid diagnostic testing.Talya FinnFrida BabushkinKeren GellerHanna AlexanderSvetlana PaikinJonathan LelloucheYafit Atiya-NasagiRegev CohenPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009573 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Talya Finn Frida Babushkin Keren Geller Hanna Alexander Svetlana Paikin Jonathan Lellouche Yafit Atiya-Nasagi Regev Cohen Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018.
description	<h4>Introduction</h4>Acute Q fever is endemic in Israel, yet the clinical and laboratory picture is poorly defined.<h4>Methods</h4>A retrospective study reviewing the medical records of acute Q fever patients, conducted in a single hospital in the Sharon district, Israel. Serum samples from suspected cases were preliminary tested by a qualitative enzyme immunoassay (EIA). Confirmatory testing at the reference laboratory used an indirect immunofluorescence assay (IFA). Positive cases were defined as fever with at least one other symptom and accepted laboratory criteria such as a single-phase II immunoglobulin G (IgG) antibody titer ≥1:200. Cases not fulfilling these criteria and in which acute Q fever was excluded, served as a control group.<h4>Results</h4>Between January 2012 and May 2018, 484 patients tested positive. After confirmatory testing, 65 (13.4%) were positive for acute Q fever (with requisite clinical picture), 171 (35.3%) were definitely not infected, the remaining 248 were excluded because of past/chronic/undetermined infection. The average age was 58 years and 66% were males. Most resided in urban areas with rare animal exposure. Pneumonia was seen in 57% of cases and a combination with headache/hepatitis was highly suggestive of acute Q fever diagnosis. Syncope/presyncope, fall and arthritis were more common in acute Q fever cases. Laboratory indexes were similar to the control group, except for erythrocyte sedimentation rate (ESR) which was more common and higher in the study group.<h4>Conclusion</h4>Acute Q fever in the Sharon district could be better diagnosed by using a syndromic approach in combination with improved rapid diagnostic testing.
format	article
author	Talya Finn Frida Babushkin Keren Geller Hanna Alexander Svetlana Paikin Jonathan Lellouche Yafit Atiya-Nasagi Regev Cohen
author_facet	Talya Finn Frida Babushkin Keren Geller Hanna Alexander Svetlana Paikin Jonathan Lellouche Yafit Atiya-Nasagi Regev Cohen
author_sort	Talya Finn
title	Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018.
title_short	Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018.
title_full	Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018.
title_fullStr	Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018.
title_full_unstemmed	Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018.
title_sort	epidemiological, clinical and laboratory features of acute q fever in a cohort of hospitalized patients in a regional hospital, israel, 2012-2018.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6d17794663aa42ffa5b1bebeb17cecc1
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Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018.

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