Efek Pemberian Kombinasi Siprofloksasin dan A-Mangostin Secara In Vitro Terhadap Eradikasi Uropatogen Escherichia Coli

Background: The percentage of resistance Escherichia coli (E. coli) in patients with UTI to ciprofloxacin reached 73.04%. Various attempts to maximize the use of antibiotics have been done, including optimizing the parameters pharmacokinetics/pharmacodynamics (PK / PD) of each antibiotic. Another ef...

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Autores principales:	Maya Dian Rakhmawatie, Afiana Rohmani
Formato:	article
Lenguaje:	EN ID
Publicado:	Universitas Muhammadiyah Semarang 2016
Materias:	ciprofloxacin a-mangostin uropathogen e. coli Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6d1900a8ae5e40069967a00428e0e0fe
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spelling	oai:doaj.org-article:6d1900a8ae5e40069967a00428e0e0fe2021-11-10T03:15:17ZEfek Pemberian Kombinasi Siprofloksasin dan A-Mangostin Secara In Vitro Terhadap Eradikasi Uropatogen Escherichia Coli2407-05052774-231810.26714/magnamed.1.2.2015.191-199https://doaj.org/article/6d1900a8ae5e40069967a00428e0e0fe2016-05-01T00:00:00Zhttps://jurnal.unimus.ac.id/index.php/APKKM/article/view/1936https://doaj.org/toc/2407-0505https://doaj.org/toc/2774-2318Background: The percentage of resistance Escherichia coli (E. coli) in patients with UTI to ciprofloxacin reached 73.04%. Various attempts to maximize the use of antibiotics have been done, including optimizing the parameters pharmacokinetics/pharmacodynamics (PK / PD) of each antibiotic. Another effort is needed to optimize the use of antibiotic treatment that has been available, one of which combines the use of compounds derived from herbs, eg active compounds a-mangostin. Objective: The purpose of this study is to find the effect of the combination of á-mangostin and ciprofloxacin on uropathogen E. coli (UPEC) eradication. Methods: This research was carried out by treating the bacteria uropathogenE. coli (UPEC) in vitro. Treatment is divided into (a) treatment groups using ciprofloxacin concentration Cmax at 500 mg dose (2,4 μg/mL), (b) treatment groups using ciprofloxacin concentration Cmax at 750 mg dose (4,3 μg/mL), (c) treatment groups using ciprofloxacin concentration 2,4 μg/mL and a-mangostin concentration 0,18 μg/mL, (d) treatment groups using ciprofloxacin concentration 4,3 μg/mL and a-mangostin concentration 0,18 μg/mL. Result: states that a combination of á-mangostin and ciprofloxacin can prevent the growth of uropathogen E. coli ciprofloxacin-resistant strains (MIC value of 128 μg/mL) compared to administration of ciprofloxacin alone, but the effect was not significant. On uropathogen E coli sensitive to ciprofloxacin (MIC 0,008 μg/mL) and intermediate (MIC 0,5 μg/mL), there was no difference effect of decreasing the number of colonies between awarding a combination of ciprofloxacin and á-mangostin compared administering ciprofloxacin only. Conclusion: Provision of á-mangostin grading 0,18 μg/mL combined with ciprofloxacin had no real benefit in eradicating uropathogen E. coli, which is tested in vitro.Maya Dian RakhmawatieAfiana RohmaniUniversitas Muhammadiyah Semarangarticleciprofloxacina-mangostinuropathogene. coliMedicine (General)R5-920ENIDMagna Medika, Vol 1, Iss 2, Pp 191-199 (2016)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	ciprofloxacin a-mangostin uropathogen e. coli Medicine (General) R5-920
spellingShingle	ciprofloxacin a-mangostin uropathogen e. coli Medicine (General) R5-920 Maya Dian Rakhmawatie Afiana Rohmani Efek Pemberian Kombinasi Siprofloksasin dan A-Mangostin Secara In Vitro Terhadap Eradikasi Uropatogen Escherichia Coli
description	Background: The percentage of resistance Escherichia coli (E. coli) in patients with UTI to ciprofloxacin reached 73.04%. Various attempts to maximize the use of antibiotics have been done, including optimizing the parameters pharmacokinetics/pharmacodynamics (PK / PD) of each antibiotic. Another effort is needed to optimize the use of antibiotic treatment that has been available, one of which combines the use of compounds derived from herbs, eg active compounds a-mangostin. Objective: The purpose of this study is to find the effect of the combination of á-mangostin and ciprofloxacin on uropathogen E. coli (UPEC) eradication. Methods: This research was carried out by treating the bacteria uropathogenE. coli (UPEC) in vitro. Treatment is divided into (a) treatment groups using ciprofloxacin concentration Cmax at 500 mg dose (2,4 μg/mL), (b) treatment groups using ciprofloxacin concentration Cmax at 750 mg dose (4,3 μg/mL), (c) treatment groups using ciprofloxacin concentration 2,4 μg/mL and a-mangostin concentration 0,18 μg/mL, (d) treatment groups using ciprofloxacin concentration 4,3 μg/mL and a-mangostin concentration 0,18 μg/mL. Result: states that a combination of á-mangostin and ciprofloxacin can prevent the growth of uropathogen E. coli ciprofloxacin-resistant strains (MIC value of 128 μg/mL) compared to administration of ciprofloxacin alone, but the effect was not significant. On uropathogen E coli sensitive to ciprofloxacin (MIC 0,008 μg/mL) and intermediate (MIC 0,5 μg/mL), there was no difference effect of decreasing the number of colonies between awarding a combination of ciprofloxacin and á-mangostin compared administering ciprofloxacin only. Conclusion: Provision of á-mangostin grading 0,18 μg/mL combined with ciprofloxacin had no real benefit in eradicating uropathogen E. coli, which is tested in vitro.
format	article
author	Maya Dian Rakhmawatie Afiana Rohmani
author_facet	Maya Dian Rakhmawatie Afiana Rohmani
author_sort	Maya Dian Rakhmawatie
title	Efek Pemberian Kombinasi Siprofloksasin dan A-Mangostin Secara In Vitro Terhadap Eradikasi Uropatogen Escherichia Coli
title_short	Efek Pemberian Kombinasi Siprofloksasin dan A-Mangostin Secara In Vitro Terhadap Eradikasi Uropatogen Escherichia Coli
title_full	Efek Pemberian Kombinasi Siprofloksasin dan A-Mangostin Secara In Vitro Terhadap Eradikasi Uropatogen Escherichia Coli
title_fullStr	Efek Pemberian Kombinasi Siprofloksasin dan A-Mangostin Secara In Vitro Terhadap Eradikasi Uropatogen Escherichia Coli
title_full_unstemmed	Efek Pemberian Kombinasi Siprofloksasin dan A-Mangostin Secara In Vitro Terhadap Eradikasi Uropatogen Escherichia Coli
title_sort	efek pemberian kombinasi siprofloksasin dan a-mangostin secara in vitro terhadap eradikasi uropatogen escherichia coli
publisher	Universitas Muhammadiyah Semarang
publishDate	2016
url	https://doaj.org/article/6d1900a8ae5e40069967a00428e0e0fe
work_keys_str_mv	AT mayadianrakhmawatie efekpemberiankombinasisiprofloksasindanamangostinsecarainvitroterhadaperadikasiuropatogenescherichiacoli AT afianarohmani efekpemberiankombinasisiprofloksasindanamangostinsecarainvitroterhadaperadikasiuropatogenescherichiacoli
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Efek Pemberian Kombinasi Siprofloksasin dan A-Mangostin Secara In Vitro Terhadap Eradikasi Uropatogen Escherichia Coli

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