Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by <italic toggle="yes">Legionella</italic>

ABSTRACT Through coevolution with host cells, microorganisms have acquired mechanisms to avoid the detection by the host surveillance system and to use the cell’s supplies to establish themselves. Indeed, certain pathogens have evolved proteins that imitate specific eukaryotic cell proteins, allowin...

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Autores principales:	Sonia Mondino, Silke Schmidt, Carmen Buchrieser
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	molecular mimicry eukaryotic-like proteins Legionella amoeba-resistant bacteria host-pathogen interactions Legionella pneumophila Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6d1b5ad0e1714d00a1c8fbe23676a0da
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spelling	oai:doaj.org-article:6d1b5ad0e1714d00a1c8fbe23676a0da2021-11-15T16:19:10ZMolecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by <italic toggle="yes">Legionella</italic>10.1128/mBio.01201-202150-7511https://doaj.org/article/6d1b5ad0e1714d00a1c8fbe23676a0da2020-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01201-20https://doaj.org/toc/2150-7511ABSTRACT Through coevolution with host cells, microorganisms have acquired mechanisms to avoid the detection by the host surveillance system and to use the cell’s supplies to establish themselves. Indeed, certain pathogens have evolved proteins that imitate specific eukaryotic cell proteins, allowing them to manipulate host pathways, a phenomenon termed molecular mimicry. Bacterial “eukaryotic-like proteins” are a remarkable example of molecular mimicry. They are defined as proteins that strongly resemble eukaryotic proteins or that carry domains that are predominantly present in eukaryotes and that are generally absent from prokaryotes. The widest diversity of eukaryotic-like proteins known to date can be found in members of the bacterial genus Legionella, some of which cause a severe pneumonia in humans. The characterization of a number of these proteins shed light on their importance during infection. The subsequent identification of eukaryotic-like genes in the genomes of other amoeba-associated bacteria and bacterial symbionts suggested that eukaryotic-like proteins are a common means of bacterial evasion and communication, shaped by the continuous interactions between bacteria and their protozoan hosts. In this review, we discuss the concept of molecular mimicry using Legionella as an example and show that eukaryotic-like proteins effectively manipulate host cell pathways. The study of the function and evolution of such proteins is an exciting field of research that is leading us toward a better understanding of the complex world of bacterium-host interactions. Ultimately, this knowledge will teach us how host pathways are manipulated and how infections may possibly be tackled.Sonia MondinoSilke SchmidtCarmen BuchrieserAmerican Society for Microbiologyarticlemolecular mimicryeukaryotic-like proteinsLegionellaamoeba-resistant bacteriahost-pathogen interactionsLegionella pneumophilaMicrobiologyQR1-502ENmBio, Vol 11, Iss 5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	molecular mimicry eukaryotic-like proteins Legionella amoeba-resistant bacteria host-pathogen interactions Legionella pneumophila Microbiology QR1-502
spellingShingle	molecular mimicry eukaryotic-like proteins Legionella amoeba-resistant bacteria host-pathogen interactions Legionella pneumophila Microbiology QR1-502 Sonia Mondino Silke Schmidt Carmen Buchrieser Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by <italic toggle="yes">Legionella</italic>
description	ABSTRACT Through coevolution with host cells, microorganisms have acquired mechanisms to avoid the detection by the host surveillance system and to use the cell’s supplies to establish themselves. Indeed, certain pathogens have evolved proteins that imitate specific eukaryotic cell proteins, allowing them to manipulate host pathways, a phenomenon termed molecular mimicry. Bacterial “eukaryotic-like proteins” are a remarkable example of molecular mimicry. They are defined as proteins that strongly resemble eukaryotic proteins or that carry domains that are predominantly present in eukaryotes and that are generally absent from prokaryotes. The widest diversity of eukaryotic-like proteins known to date can be found in members of the bacterial genus Legionella, some of which cause a severe pneumonia in humans. The characterization of a number of these proteins shed light on their importance during infection. The subsequent identification of eukaryotic-like genes in the genomes of other amoeba-associated bacteria and bacterial symbionts suggested that eukaryotic-like proteins are a common means of bacterial evasion and communication, shaped by the continuous interactions between bacteria and their protozoan hosts. In this review, we discuss the concept of molecular mimicry using Legionella as an example and show that eukaryotic-like proteins effectively manipulate host cell pathways. The study of the function and evolution of such proteins is an exciting field of research that is leading us toward a better understanding of the complex world of bacterium-host interactions. Ultimately, this knowledge will teach us how host pathways are manipulated and how infections may possibly be tackled.
format	article
author	Sonia Mondino Silke Schmidt Carmen Buchrieser
author_facet	Sonia Mondino Silke Schmidt Carmen Buchrieser
author_sort	Sonia Mondino
title	Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by <italic toggle="yes">Legionella</italic>
title_short	Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by <italic toggle="yes">Legionella</italic>
title_full	Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by <italic toggle="yes">Legionella</italic>
title_fullStr	Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by <italic toggle="yes">Legionella</italic>
title_full_unstemmed	Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by <italic toggle="yes">Legionella</italic>
title_sort	molecular mimicry: a paradigm of host-microbe coevolution illustrated by <italic toggle="yes">legionella</italic>
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/6d1b5ad0e1714d00a1c8fbe23676a0da
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Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by <italic toggle="yes">Legionella</italic>

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