Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis.

<h4>Background</h4>Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects of the disease and to refine treatment strategies but also to improve clinical decision-making. For clinical decision-making in particular, prognostic fac...

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Autores principales:	Martin Kieninger, Annemarie Sinning, Timea Vadász, Michael Gruber, Wolfram Gronwald, Florian Zeman, Dirk Lunz, Thomas Dienemann, Stephan Schmid, Bernhard Graf, Matthias Lubnow, Thomas Müller, Thomas Holzmann, Bernd Salzberger, Bärbel Kieninger
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d1d7d3a4ef24336978db96c47632783
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spelling	oai:doaj.org-article:6d1d7d3a4ef24336978db96c476327832021-11-25T06:18:59ZLower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis.1932-620310.1371/journal.pone.0258018https://doaj.org/article/6d1d7d3a4ef24336978db96c476327832021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258018https://doaj.org/toc/1932-6203<h4>Background</h4>Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects of the disease and to refine treatment strategies but also to improve clinical decision-making. For clinical decision-making in particular, prognostic factors of a lethal course of the disease would be highly relevant.<h4>Methods</h4>In this retrospective cohort study, we analyzed the first 59 adult critically ill Covid-19 patients treated in one of the intensive care units of the University Medical Center Regensburg, Germany. Using uni- and multivariable regression models, we extracted a set of parameters that allowed for prognosing in-hospital mortality.<h4>Results</h4>Within the cohort, 19 patients died (mortality 32.2%). Blood pH value, mean arterial pressure, base excess, troponin, and procalcitonin were identified as highly significant prognostic factors of in-hospital mortality. However, no significant differences were found for other parameters expected to be relevant prognostic factors, like low arterial partial pressure of oxygen or high lactate levels. In the multivariable logistic regression analysis, the pH value and the mean arterial pressure turned out to be the most influential prognostic factors for a lethal course.Martin KieningerAnnemarie SinningTimea VadászMichael GruberWolfram GronwaldFlorian ZemanDirk LunzThomas DienemannStephan SchmidBernhard GrafMatthias LubnowThomas MüllerThomas HolzmannBernd SalzbergerBärbel KieningerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0258018 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martin Kieninger Annemarie Sinning Timea Vadász Michael Gruber Wolfram Gronwald Florian Zeman Dirk Lunz Thomas Dienemann Stephan Schmid Bernhard Graf Matthias Lubnow Thomas Müller Thomas Holzmann Bernd Salzberger Bärbel Kieninger Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis.
description	<h4>Background</h4>Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects of the disease and to refine treatment strategies but also to improve clinical decision-making. For clinical decision-making in particular, prognostic factors of a lethal course of the disease would be highly relevant.<h4>Methods</h4>In this retrospective cohort study, we analyzed the first 59 adult critically ill Covid-19 patients treated in one of the intensive care units of the University Medical Center Regensburg, Germany. Using uni- and multivariable regression models, we extracted a set of parameters that allowed for prognosing in-hospital mortality.<h4>Results</h4>Within the cohort, 19 patients died (mortality 32.2%). Blood pH value, mean arterial pressure, base excess, troponin, and procalcitonin were identified as highly significant prognostic factors of in-hospital mortality. However, no significant differences were found for other parameters expected to be relevant prognostic factors, like low arterial partial pressure of oxygen or high lactate levels. In the multivariable logistic regression analysis, the pH value and the mean arterial pressure turned out to be the most influential prognostic factors for a lethal course.
format	article
author	Martin Kieninger Annemarie Sinning Timea Vadász Michael Gruber Wolfram Gronwald Florian Zeman Dirk Lunz Thomas Dienemann Stephan Schmid Bernhard Graf Matthias Lubnow Thomas Müller Thomas Holzmann Bernd Salzberger Bärbel Kieninger
author_facet	Martin Kieninger Annemarie Sinning Timea Vadász Michael Gruber Wolfram Gronwald Florian Zeman Dirk Lunz Thomas Dienemann Stephan Schmid Bernhard Graf Matthias Lubnow Thomas Müller Thomas Holzmann Bernd Salzberger Bärbel Kieninger
author_sort	Martin Kieninger
title	Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis.
title_short	Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis.
title_full	Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis.
title_fullStr	Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis.
title_full_unstemmed	Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis.
title_sort	lower blood ph as a strong prognostic factor for fatal outcomes in critically ill covid-19 patients at an intensive care unit: a multivariable analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6d1d7d3a4ef24336978db96c47632783
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Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis.

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