Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Appraisal of the Available Clinical Evidence

Hong Xiao,1 Dan Xu,2 Rui Mao,3 Minqin Xiao,1 Yang Fang,4 Yin Liu1 1Department of Plastic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 2Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunmin...

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Autores principales:	Xiao H, Xu D, Mao R, Xiao M, Fang Y, Liu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	fibrin hyaluronic acid platelet-rich plasma rejuvenation wound healing Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/6d1f0c07155d471aa80b480ac512cd66
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spelling	oai:doaj.org-article:6d1f0c07155d471aa80b480ac512cd662021-11-16T18:47:51ZPlatelet-Rich Plasma in Facial Rejuvenation: A Systematic Appraisal of the Available Clinical Evidence1178-7015https://doaj.org/article/6d1f0c07155d471aa80b480ac512cd662021-11-01T00:00:00Zhttps://www.dovepress.com/platelet-rich-plasma-in-facial-rejuvenation-a-systematic-appraisal-of--peer-reviewed-fulltext-article-CCIDhttps://doaj.org/toc/1178-7015Hong Xiao,1 Dan Xu,2 Rui Mao,3 Minqin Xiao,1 Yang Fang,4 Yin Liu1 1Department of Plastic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 2Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 3School of Stomatology, Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 4Wushi Jiamei Beauty Hospital, Kunming, Yunnan, People’s Republic of ChinaCorrespondence: Yin LiuDepartment of Plastic Surgery, The Second Affiliated Hospital of Kunming Medical University, No. 374, Dianmian Road, Kunming, Yunnan, 650103, People’s Republic of ChinaTel +86-136 5888 3652Email liuyinsky@163.comPurpose: Platelet-rich plasma (PRP) is a promising noninvasive technique for facial rejuvenation. This systematic literature review aims to appraise the nature and quality of published evidence evaluating the effectiveness and safety of PRP in facial rejuvenation.Patients and Methods: A systematic literature review was conducted with the search string “Platelet-rich plasma AND Facial rejuvenation” in PubMed and Embase. Clinical studies evaluating the outcomes after PRP-based facial rejuvenation either as monotherapy or in combination with other treatment modalities were included. Studies evaluating wound-healing properties of PRP were excluded. The outcomes included both patient-reported and physician-assessed outcomes. Nonstatistical synthesis of evidence was performed by qualitative assessment. The results are reported by the Synthesis Without Meta-analysis (SWiM) reporting standard.Results: A total of 36 studies that included a total of 3172 patients were considered for the evidence synthesis. The number of patients in the included studies ranging from 11 to 2005 with a median of 27.5 patients that reflects the challenges in clinically assessing the aesthetic outcomes after PRP-based facial rejuvenation. Among the 36 studies, 17 were observational studies and 18 were interventional studies with 1 being case report PRP was evaluated either alone or in combination with hyaluronic acid, lipofilling, micro-needling technique, and laser-based interventions. Among the studies, 1 study reported the enhanced platelet concentrate in a fibrin matrix to be relatively safe and effective with a maximum benefit observed at 12 weeks suggesting the platelet-rich fibrin matrix may provide desired aesthetic outcomes and it requires further studies to substantiate.Conclusion: The results suggest very limited clinical evidence, and further clinical studies are warranted to establish the effectiveness of PRP in facial rejuvenation. Furthermore, a consensus for end points used for establishing clinical utility in patients requiring facial rejuvenation is warranted.Keywords: fibrin, hyaluronic acid, platelet-rich plasma, rejuvenation, wound healingXiao HXu DMao RXiao MFang YLiu YDove Medical Pressarticlefibrinhyaluronic acidplatelet-rich plasmarejuvenationwound healingDermatologyRL1-803ENClinical, Cosmetic and Investigational Dermatology, Vol Volume 14, Pp 1697-1724 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibrin hyaluronic acid platelet-rich plasma rejuvenation wound healing Dermatology RL1-803
spellingShingle	fibrin hyaluronic acid platelet-rich plasma rejuvenation wound healing Dermatology RL1-803 Xiao H Xu D Mao R Xiao M Fang Y Liu Y Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Appraisal of the Available Clinical Evidence
description	Hong Xiao,1 Dan Xu,2 Rui Mao,3 Minqin Xiao,1 Yang Fang,4 Yin Liu1 1Department of Plastic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 2Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 3School of Stomatology, Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 4Wushi Jiamei Beauty Hospital, Kunming, Yunnan, People’s Republic of ChinaCorrespondence: Yin LiuDepartment of Plastic Surgery, The Second Affiliated Hospital of Kunming Medical University, No. 374, Dianmian Road, Kunming, Yunnan, 650103, People’s Republic of ChinaTel +86-136 5888 3652Email liuyinsky@163.comPurpose: Platelet-rich plasma (PRP) is a promising noninvasive technique for facial rejuvenation. This systematic literature review aims to appraise the nature and quality of published evidence evaluating the effectiveness and safety of PRP in facial rejuvenation.Patients and Methods: A systematic literature review was conducted with the search string “Platelet-rich plasma AND Facial rejuvenation” in PubMed and Embase. Clinical studies evaluating the outcomes after PRP-based facial rejuvenation either as monotherapy or in combination with other treatment modalities were included. Studies evaluating wound-healing properties of PRP were excluded. The outcomes included both patient-reported and physician-assessed outcomes. Nonstatistical synthesis of evidence was performed by qualitative assessment. The results are reported by the Synthesis Without Meta-analysis (SWiM) reporting standard.Results: A total of 36 studies that included a total of 3172 patients were considered for the evidence synthesis. The number of patients in the included studies ranging from 11 to 2005 with a median of 27.5 patients that reflects the challenges in clinically assessing the aesthetic outcomes after PRP-based facial rejuvenation. Among the 36 studies, 17 were observational studies and 18 were interventional studies with 1 being case report PRP was evaluated either alone or in combination with hyaluronic acid, lipofilling, micro-needling technique, and laser-based interventions. Among the studies, 1 study reported the enhanced platelet concentrate in a fibrin matrix to be relatively safe and effective with a maximum benefit observed at 12 weeks suggesting the platelet-rich fibrin matrix may provide desired aesthetic outcomes and it requires further studies to substantiate.Conclusion: The results suggest very limited clinical evidence, and further clinical studies are warranted to establish the effectiveness of PRP in facial rejuvenation. Furthermore, a consensus for end points used for establishing clinical utility in patients requiring facial rejuvenation is warranted.Keywords: fibrin, hyaluronic acid, platelet-rich plasma, rejuvenation, wound healing
format	article
author	Xiao H Xu D Mao R Xiao M Fang Y Liu Y
author_facet	Xiao H Xu D Mao R Xiao M Fang Y Liu Y
author_sort	Xiao H
title	Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Appraisal of the Available Clinical Evidence
title_short	Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Appraisal of the Available Clinical Evidence
title_full	Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Appraisal of the Available Clinical Evidence
title_fullStr	Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Appraisal of the Available Clinical Evidence
title_full_unstemmed	Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Appraisal of the Available Clinical Evidence
title_sort	platelet-rich plasma in facial rejuvenation: a systematic appraisal of the available clinical evidence
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6d1f0c07155d471aa80b480ac512cd66
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Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Appraisal of the Available Clinical Evidence

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